Analysis of predictive factors associated with the reversibility of post-transplantation diabetes mellitus

  Objective   To investigate the predictive factors associated with the reversibility of post-transplantation diabetes mellitus(PTDM).

  Method   Clinical data of 618 patients who underwent liver transplantation from April 2004 to June 2009 in the Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed, in which 190 patients were included in the study. According to the persistence of hyperglycemia, patients were divided into two groups: reversible PTDM group and irreversible PTDM group. Preoperative data (age, gender, body mass index, pre-transplantation fasting plasma glucose, liver cirrhosis history, hypertension history) and postoperative data (rejection, dose of glucocorticoid, choice of calcineurin inhibitor) which might affect the glycometabolism of patients between two groups were analyzed by univariate factor analysis.

  Result   PTDM in 102 patients (69.9%) was reversible. Compared with irreversible PTDM group, age of patients was younger in reversible PTDM group(43±11)years old vs. (52±10)years old, P<0.05. And there was no significant difference in the other factors(all in P>0.05).

  Conclusion   Age of patients received organ transplantation is the predictive factor associated with the reversibility of PTDM.