线粒体融合蛋白2与缺血-再灌注损伤

欧志宇; 苗芸

doi:10.3969/j.issn.1674-7445.2022.02.019

线粒体融合蛋白2与缺血-再灌注损伤

doi: 10.3969/j.issn.1674-7445.2022.02.019

欧志宇,
苗芸^,

510515 广州，南方医科大学南方医院器官移植科

基金项目:

国家自然科学基金 82070770

广东省自然科学基金 2020A1515010674

广州市科技计划项目 201803010109

南方医院院长基金 2018B009

南方医院院长基金 2018C003

大学生创新创业训练计划项目 202012121046

大学生创新创业训练计划项目 X202012121239

详细信息

作者简介:

通讯作者:
苗芸，女，1978年生，博士，主任医师，研究方向为肾移植，Email：miaoyunecho@126.com

中图分类号: R617, Q731
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-16
- 网络出版日期: 2022-03-18
- 刊出日期: 2022-03-15

Mitofusin 2 and ischemia-reperfusion injury

Ou Zhiyu,
Miao Yun^,

Department of Organ Transplantation, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

More Information

Corresponding author: Miao Yun, Email: miaoyunecho@126.com

摘要

摘要: 线粒体是重要的细胞器之一，由线粒体外膜和线粒体内膜组成，其结构和功能受线粒体动力学调控。线粒体融合相关蛋白和线粒体分裂相关蛋白可参与线粒体融合和分裂过程，调控线粒体动力学，进而调节细胞结构、功能及能量代谢。其中线粒体融合蛋白(MFN)2是一种位于哺乳动物线粒体外膜上的蛋白，具有三磷酸鸟苷酶活性，可介导线粒体融合，参与线粒体自噬、线粒体-内质网结构偶联的形成和细胞凋亡等生理过程，并可显著影响缺血-再灌注损伤(IRI)的发生发展。本文综述MFN2的结构与调节、MFN2的功能、MFN2在IRI中作用的相关文献，探讨MFN2与IRI的关系及相关机制，以期为IRI的防治提供新的靶点和思路。
- 线粒体融合蛋白2 /
- 缺血-再灌注损伤 /
- 线粒体融合 /
- 线粒体分裂 /
- 线粒体自噬 /
- 线粒体相关的内质网膜结构 /
- 三磷酸鸟苷酶 /
- 细胞凋亡
Abstract: Mitochondria is one of the important organelles, which is composed of outer mitochondrial membrane and inner mitochondrial membrane. Mitochondrial structure and function are regulated by mitochondrial dynamics. Mitochondrial fusion- and fission-related proteins may participate in the process of mitochondrial fusion and fission, mediate mitochondrial dynamics, thereby regulating cell structure, function and energy metabolism. Mitofusin (MFN) 2, a protein located on the outer mitochondrial membrane of mammalian, has guanosine triphosphatase activity, which may mediate mitochondrial fusion, participate in mitophagy, formation of mitochondria-associated endoplasmic reticulum membrane and apoptosis, and significantly affect the incidence and development of ischemia-reperfusion injury (IRI). In this article, the structure, regulation, function of MFN2 and its role in IRI were reviewed, and the relationship between MFN2 and IRI and underlying mechanism were investigated, aiming to provide novel targets and ideas for the prevention and treatment of IRI.
- Mitofusin 2 /
- Ischemia-reperfusion injury /
- Mitochondrial fusion /
- Mitochondrial fission /
- Mitophagy /
- Mitochondria-associated endoplasmic reticulum membrane /
- Guanosine triphosphatase /
- Apoptosis

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图 1 MFN2的结构及其功能

注：A图为MFN2的结构; B图为线粒体融合; C图为线粒体自噬; D图为MAM。

Figure 1. Structure and function of MFN2

下载: 全尺寸图片幻灯片

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