生物3D打印在器官再造中的前沿热点和研究进展

黄文华

doi:10.3969/j.issn.1674-7445.2022.02.003

生物3D打印在器官再造中的前沿热点和研究进展

doi: 10.3969/j.issn.1674-7445.2022.02.003

黄文华^,

510515 广州，南方医科大学基础医学院人体解剖学国家重点学科广东省医学生物力学重点实验室广东省医学3D打印应用转化工程技术研究中心

基金项目:

国家自然科学基金 21773199

国家自然科学基金 31972915

广东省基础与应用基础研究基金 2020B1515120001

深圳市医疗卫生“三名工程”高层次医学团队 SZSM201612019

详细信息

作者简介:

通讯作者:
黄文华，Email：huangwenhua2009@139.com

中图分类号: R617, R318.1
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-24
- 网络出版日期: 2022-03-18
- 刊出日期: 2022-03-15

Frontier hotspots and research progress on 3D bioprinting in organ reconstruction

Huang Wenhua^,

National Key Discipline of Human Anatomy, School of Basic Medical Science, Southern Medical University, Guangdong Provincial Key Laboratory of Medical Biomechanics, Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangzhou 510515, China

More Information

Corresponding author: Huang Wenhua, Email: huangwenhua2009@139.com

摘要

摘要: 生物3D打印是采用生物材料和生物活性成分制作人工组织器官的新兴制造技术，已在多个医学领域广泛应用，在器官再造领域也具有突出的优势。近年来，生物3D打印器官取得了一系列重要突破，但目前仍处在研发和探索阶段，存在较多瓶颈，尚还不能用于体内移植。本文主要就3D打印技术的医学应用，生物3D打印技术的特点，生物3D打印器官在仿生结构、功能重建、免疫反应等方面的研究热点和难点，以及生物3D打印的最新研究进展，阐述生物3D打印技术在器官再造领域的应用前景，为器官重建、人工器官构建的研究及其临床应用提供新思路，以推动器官移植和个性化医疗的发展。
- 生物3D打印 /
- 器官再造 /
- 器官移植 /
- 器官芯片 /
- 免疫反应 /
- 功能重建 /
- 仿生结构 /
- 血管化
Abstract: 3D bioprinting is an advanced manufacturing technology that utilizes biomaterials and bioactive components to manufacture artificial tissues and organs. It has been widely applied in multiple medical fields and possesses outstanding advantages in organ reconstruction. In recent years, 3D bioprinted organs have made an array of groundbreaking achievements. Nevertheless, it is still in the exploratory stage of research and development and still has bottleneck problems, which can not be applied in organ transplantation in vivo. In this article, the application of 3D printing technology in medicine, characteristics of 3D bioprinting technology, research hotspots and difficulties in bionic structure, functional reconstruction and immune response of 3D bioprinted organs, and the latest research progress on 3D bioprinting technology were illustrated, and the application prospect of 3D bioprinting technology in the field of organ reconstruction was elucidated, aiming to provide novel ideas for the research and clinical application of organ reconstruction and artificial organ reconstruction, and promote the development of organ transplantation and individualized medicine.
- 3D bioprinting /
- Organ reconstruction /
- Organ Transplantation /
- Organ-on-a-chip /
- Immune response /
- Functional reconstruction /
- Bionic structure /
- Vascularization

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