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间充质干细胞治疗缺血性胆道损伤的研究进展

代鑫 程龙 王强 骆助林 汪涛

代鑫, 程龙, 王强, 等. 间充质干细胞治疗缺血性胆道损伤的研究进展[J]. 器官移植, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
引用本文: 代鑫, 程龙, 王强, 等. 间充质干细胞治疗缺血性胆道损伤的研究进展[J]. 器官移植, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
Dai Xin, Cheng Long, Wang Qiang, et al. Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016
Citation: Dai Xin, Cheng Long, Wang Qiang, et al. Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion[J]. ORGAN TRANSPLANTATION, 2021, 12(6): 748-753. doi: 10.3969/j.issn.1674-7445.2021.06.016

间充质干细胞治疗缺血性胆道损伤的研究进展

doi: 10.3969/j.issn.1674-7445.2021.06.016
基金项目: 

四川省青年科技基金项目 2016JQ0023

详细信息
    作者简介:

    代鑫,男,1994年生,硕士研究生,住院医师,研究方向为肝胆疾病基础与临床,Email:daision1994@163.com

    通讯作者:

    汪涛,男,1968年生,主任医师,研究方向为肝胆胰疾病外科微创治疗,Email:watopo@163.com

  • 中图分类号: R617, R392.12

Research progress on mesenchymal stem cell in treatment of ischemic-type biliary lesion

More Information
  • 摘要: 目前,缺血性胆道损伤(ITBL)的临床治疗仍以外科手术、内镜治疗等方法为主,具有治疗策略单一、治疗方法难度大和医疗费用高的缺点,亟需寻找一种新的治疗策略。间充质干细胞(MSC)具有高度的自我更新能力、多向分化潜能、低免疫原性及免疫调节作用等特性,已然成为再生医学中组织和器官修复的潜在种子细胞。近年来众多研究发现,MSC移植到ITBL动物模型后,不但可归巢到损伤区域,而且可通过抗凋亡、促血管新生等作用促进损伤胆道组织的修复,这表明MSC移植有望成为治疗ITBL的新策略。本文对MSC的生物学特性、MSC移植治疗ITBL的机制及其临床应用做一综述。

     

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  • 收稿日期:  2021-07-15
  • 刊出日期:  2021-11-15

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