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低温双通道氧合机械灌注在离体劈离式肝移植中的应用

任钧楷 张彤

任钧楷, 张彤. 低温双通道氧合机械灌注在离体劈离式肝移植中的应用[J]. 器官移植, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008
引用本文: 任钧楷, 张彤. 低温双通道氧合机械灌注在离体劈离式肝移植中的应用[J]. 器官移植, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008
Ren Junkai, Zhang Tong. Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008
Citation: Ren Junkai, Zhang Tong. Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(5): 550-555. doi: 10.3969/j.issn.1674-7445.2021.05.008

低温双通道氧合机械灌注在离体劈离式肝移植中的应用

doi: 10.3969/j.issn.1674-7445.2021.05.008
基金项目: 

广东省自然科学基金 2019A1515011850

详细信息
    作者简介:

    任钧楷,男,1996年生,硕士研究生,研究方向为肝移植,Email: rjk119234@163.com

    通讯作者:

    张彤,男,1972年生,博士,主任医师,研究方向为肝移植,E-mail: zhjeff72@sina.com

  • 中图分类号: R617

Application of dual hypothermic oxygenated machine perfusion in ex vivo split liver transplantation

More Information
  • 摘要: 随着劈离式肝移植的飞速开展,其技术日趋成熟。离体劈离时,由于细胞内能量来源[如三磷酸腺苷(ATP)]的耗竭以及其他代谢紊乱,导致细胞损伤和功能障碍,这种损伤会因肝移植再灌注损伤而加重,临床上表现为移植术后并发症和移植失败。为了进一步改善离体劈离式肝移植的供肝质量,国内外研究团队使用机械灌注来改善供肝质量。本文结合了国际上离体劈离式肝移植供肝机械灌注的研究进展,阐述了低温双通道氧合机械灌注(D-HOPE)在离体劈离式肝移植中的应用和未来发展方向,旨在为增加离体劈离式肝移植的供肝来源,进一步改善供肝短缺的现状提供参考。

     

  • 表  1  D-HOPE在离体劈离式肝移植中应用的文献报道

    Table  1.   Literature reports on the application of D-HOPE in ex vivo split liver transplantation

    研究者 年份 供者 灌注温度 灌注方式 灌注压力 移植肝叶 D-HOPE时间(min) SCS时间(min) 总灌注时间(min)
    Spada, et al[3] 2020年 19岁DBD供者 10 ℃ Belzer MPS UW②机械灌注液,1 L /min 100% 氧气氧合,达到PaO2③≥450 mmHg 6/25 S2段 300 360 660
    右三叶 480 360 840
    Thorne, et al[20] 2021年 52岁DBD供者 < 10 ℃ UW机械灌注液,1 L/min 100% 氧气氧合,达到PaO2 > 795 mmHg 3/25 左外叶 125 205 330
    右三叶 152 468 620
    注:①灌注压力为门静脉(mmHg)/肝动脉(mmHg)。
    ②UW为威斯康星大学。
    ③PaO2为动脉血氧分压。
    下载: 导出CSV
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出版历程
  • 收稿日期:  2021-05-01
  • 网络出版日期:  2021-09-15
  • 刊出日期:  2021-09-15

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