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细胞外囊泡在肝移植中的应用进展

贾德功 贾志兴 郭珊珊 程颖

贾德功, 贾志兴, 郭珊珊, 等. 细胞外囊泡在肝移植中的应用进展[J]. 器官移植, 2021, 12(4): 477-483. doi: 10.3969/j.issn.1674-7445.2021.04.016
引用本文: 贾德功, 贾志兴, 郭珊珊, 等. 细胞外囊泡在肝移植中的应用进展[J]. 器官移植, 2021, 12(4): 477-483. doi: 10.3969/j.issn.1674-7445.2021.04.016
Jia Degong, Jia Zhixing, Guo Shanshan, et al. Application progress of extracellular vesicle in liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 477-483. doi: 10.3969/j.issn.1674-7445.2021.04.016
Citation: Jia Degong, Jia Zhixing, Guo Shanshan, et al. Application progress of extracellular vesicle in liver transplantation[J]. ORGAN TRANSPLANTATION, 2021, 12(4): 477-483. doi: 10.3969/j.issn.1674-7445.2021.04.016

细胞外囊泡在肝移植中的应用进展

doi: 10.3969/j.issn.1674-7445.2021.04.016
基金项目: 

河南省医学科技攻关计划联合共建项目 LHGJ20200507

新乡医学院第一附属医院青年培育基金项目 QN-2019-B05

详细信息
    作者简介:

    贾德功,男,1992年生,硕士,住院医师,研究方向为器官移植,Email:jdgqimeng@foxmail.com

    通讯作者:

    程颖,女,1975年生,博士,研究员,研究方向为器官移植,Email:chengying75@sina.com

  • 中图分类号: R617, R392.4

Application progress of extracellular vesicle in liver transplantation

More Information
  • 摘要: 肝移植是治疗终末期肝病的有效方法,而肝缺血-再灌注损伤(IRI)和排斥反应大大降低了移植肝的存活率。因此,急需一种既可以减轻肝IRI又可以促进同种异体移植物免疫耐受的新方法,以提高移植肝的存活率。细胞外囊泡(EV)是由细胞释放到细胞外微环境的纳米颗粒,可以通过修复自噬、免疫抑制和促进组织再生减轻移植物损伤。这使得EV成为肝移植领域的研究热点,但其临床应用面临着众多挑战,如EV的分离、纯化、鉴定、储存以及如何靶向递送到目标细胞等。本文对EV在肝IRI中的作用机制、EV临床应用面临的挑战及EV的潜在应用进行综述,旨在为EV在肝移植的临床应用提供参考。

     

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出版历程
  • 收稿日期:  2021-04-24
  • 网络出版日期:  2021-07-13
  • 刊出日期:  2021-07-15

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