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肝内胆管癌肝移植及其综合治疗

吴凤东 史斌

吴凤东, 史斌. 肝内胆管癌肝移植及其综合治疗[J]. 器官移植, 2021, 12(3): 344-350. doi: 10.3969/j.issn.1674-7445.2021.03.014
引用本文: 吴凤东, 史斌. 肝内胆管癌肝移植及其综合治疗[J]. 器官移植, 2021, 12(3): 344-350. doi: 10.3969/j.issn.1674-7445.2021.03.014
Wu Fengdong, Shi Bin. Liver transplantation and comprehensive treatment of intrahepatic cholangiocarcinoma[J]. ORGAN TRANSPLANTATION, 2021, 12(3): 344-350. doi: 10.3969/j.issn.1674-7445.2021.03.014
Citation: Wu Fengdong, Shi Bin. Liver transplantation and comprehensive treatment of intrahepatic cholangiocarcinoma[J]. ORGAN TRANSPLANTATION, 2021, 12(3): 344-350. doi: 10.3969/j.issn.1674-7445.2021.03.014

肝内胆管癌肝移植及其综合治疗

doi: 10.3969/j.issn.1674-7445.2021.03.014
基金项目: 

北京市自然科学基金资助项目 7202235

详细信息
    通讯作者:

    吴凤东,男,1969年生,博士,副主任医师,研究方向为肝移植,Email : 13501080376@163.com

  • 中图分类号: R617, R575.7

Liver transplantation and comprehensive treatment of intrahepatic cholangiocarcinoma

More Information
  • 摘要: 肝移植是治疗肝内胆管癌(ICC)的有效手段,由于ICC侵袭性强、易淋巴结转移,肝移植术后肿瘤复发率较高,需要严格掌握适应证。直径≤2 cm的单发ICC肝移植效果良好,进展期ICC则需先进行包括局部治疗和全身化学药物治疗(化疗)在内的新辅助治疗,根据新辅助治疗的反应决定是否进行肝移植,并于术后进行个体化辅助治疗。目前已经发现多个胆管癌基因突变靶点及靶向治疗药物。肝移植术前、术后辅以综合治疗可拓展ICC肝移植的适应证,改善受者预后。本文从ICC肝移植治疗、ICC肝移植术前新辅助治疗和术后辅助治疗以及ICC靶向治疗等方面进行综述。

     

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出版历程
  • 收稿日期:  2021-02-25
  • 网络出版日期:  2021-05-19
  • 刊出日期:  2021-05-15

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