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磁压榨吻合技术实现犬腹主动脉人工血管置换快速无缝线吻合

刘仕琪 慈红波 雷鹏 吕毅 王善佩 白纪刚

刘仕琪, 慈红波, 雷鹏, 等. 磁压榨吻合技术实现犬腹主动脉人工血管置换快速无缝线吻合[J]. 器官移植, 2021, 12(2): 191-196. doi: 10.3969/j.issn.1674-7445.2021.02.009
引用本文: 刘仕琪, 慈红波, 雷鹏, 等. 磁压榨吻合技术实现犬腹主动脉人工血管置换快速无缝线吻合[J]. 器官移植, 2021, 12(2): 191-196. doi: 10.3969/j.issn.1674-7445.2021.02.009
Liu Shiqi, Ci Hongbo, Lei Peng, et al. Rapid and sutureless anastomosis of artificial vascular replacement of abdominal aorta in dog models using magnetic compression anastomosis technique[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 191-196. doi: 10.3969/j.issn.1674-7445.2021.02.009
Citation: Liu Shiqi, Ci Hongbo, Lei Peng, et al. Rapid and sutureless anastomosis of artificial vascular replacement of abdominal aorta in dog models using magnetic compression anastomosis technique[J]. ORGAN TRANSPLANTATION, 2021, 12(2): 191-196. doi: 10.3969/j.issn.1674-7445.2021.02.009

磁压榨吻合技术实现犬腹主动脉人工血管置换快速无缝线吻合

doi: 10.3969/j.issn.1674-7445.2021.02.009
基金项目: 

国家自然科学基金 81470896

陕西省重点产业创新链(群)——社会发展领域项目 2020ZDLSF02-03

详细信息
    作者简介:

    刘仕琪,男,1975年生,博士,副主任医师,研究方向为小儿外科、肝胆外科与器官移植,Email:liushiqi23@foxmail.com

    通讯作者:

    吕毅,男,1963年生,教授,博士研究生导师,Email:luyi169@126.com

  • 中图分类号: R617, R622

Rapid and sutureless anastomosis of artificial vascular replacement of abdominal aorta in dog models using magnetic compression anastomosis technique

More Information
  • 摘要:   目的  探讨利用磁压榨吻合(MCA)技术实现犬腹主动脉人工血管置换快速无缝线吻合的可行性。  方法  选择成年健康杂交犬12只,按腹主动脉与人工血管吻合方式分为MCA组和手工缝合(HS)组,每组6只。比较两组术中腹主动脉阻断时间、术中吻合口情况与术后吻合口影像学检查情况。  结果  MCA组腹主动脉阻断时间短于HS组[(5.2±2.3)min比(24.4±4.3)min],差异有统计学意义(P < 0.001)。MCA组术中吻合口无渗漏血及狭窄情况发生;HS组术中6只犬均发生吻合口渗漏血,其中1只犬因失血过多死亡,2只犬因反复修补而出现吻合口轻度狭窄。MCA组术后彩色多普勒超声与血管造影检查显示吻合口血流通畅,无狭窄及血栓形成,HS组术后4周时血管造影检查共发现4只犬吻合口狭窄。  结论  利用MCA技术可实现犬腹主动脉人工血管置换快速无缝线吻合,减少吻合口并发症的发生,有利于术后恢复。

     

  • 图  1  腹主动脉人工血管置换磁压榨吻合术

    注:A图示ePTFE人工血管-磁性吻合环模块实物;B图示腹主动脉远、近端分别固定于吻合环上;C图示ePTFE人工血管-磁性吻合环模块两端与腹主动脉远、近端互相靠近后自动完成人工血管快速吻合;D图示腹主动脉血流恢复通畅。

    Figure  1.  Magnetic compression anastomosis for abdominal aorta replacement by artificial blood vessel

    图  2  腹主动脉人工血管置换术后影像学表现

    注:A图彩超示MCA组腹主动脉人工血管置换术后吻合口血流速度正常,无吻合口狭窄、血栓形成或湍流引起的血管壁波动;B图腹主动脉造影示MCA组术后吻合口血流通畅;C图腹主动脉造影示HS组腹主动脉人工血管置换术后吻合口狭窄。

    Figure  2.  Postoperative imaging findings after abdominal aorta replacement by artificial blood vessel

  • [1] 孙来龙, 杜剑平, 刘朝兵, 等. 一种新型大鼠动脉移植模型的建立[J]. 中国比较医学杂志, 2017, 27(5): 99-102. DOI: 10.3969.j.issn.1671-7856.2017.05.021.

    SUN LL, DU JP, LIU CB, et al. A new model of rat artery transplantation[J]. Chin J Comp Med, 2017, 27(5): 99-102. DOI: 10.3969.j.issn.1671-7856.2017.05.021.
    [2] MA GG, HAO GW, LAI H, et al. Initial clinical impact of inhaled nitric oxide therapy for refractory hypoxemia following type A acute aortic dissection surgery[J]. J Thorac Dis, 2019, 11(2): 495-504. DOI: 10.21037/jtd.2019.01.42.
    [3] MUKAIDA H, HAYASHIDA M, MATSUSHITA S, et al. Brain natriuretic peptide (BNP) may play a major role in risk stratification based on cerebral oxygen saturation by near-infrared spectroscopy in patients undergoing major cardiovascular surgery[J]. PLoS One, 2017, 12(7): e0181154. DOI: 10.1371/journal.pone.0181154.
    [4] 刘仕琪, 吕毅, 严小鹏. 恒磁场技术在血管与器官移植外科应用现状与进展[J]. 中华器官移植杂志, 2018, 39(12): 761-764. DOI:10.3760/cma.j.issn.0254-1785. 2018.12.014.

    LIU SQ, LYU Y, YAN XP. Application situation and progress of constant magnetic field technique in surgery of blood vessel and organ transplantation[J]. Chin J Organ Transplant, 2018, 39(12): 761-764. DOI: 10.3760/cma.j.issn.0254-1785.2018.12.014.
    [5] 刘仕琪, 雷鹏, 吕毅, 等. 磁压榨吻合技术快速无缝线吻合犬股动脉[J]. 中华胸心血管外科杂志, 2015, 31(1): 28-30. DOI: 10.3760/cma.j.issn.1001-4497.2015.01.008.

    LIU SQ, LEI P, LYU Y, et al. Rapid and effective sutureless anastomosis of femoral artery by magnetic compression anastomosis technique[J]. Chin J Cardiovasc Surg, 2015, 31(1): 28-30. DOI: 10.3760/cma.j.issn.1001-4497.2015.01.008.
    [6] BRIASOULIS A, AKINTOYE E, KUNO T, et al. Characteristics and outcomes of patients undergoing combined organ transplantation (from the United Network for Organ Sharing)[J]. Am J Cardiol, 2020, 129: 42-45. DOI: 10.1016/j.amjcard.2020.05.034.
    [7] BRYANT R 3RD, RIZWAN R, ZAFAR F, et al. Contemporary outcomes of combined heart-liver transplant in patients with congenital heart disease[J]. Transplantation, 2018, 102(2): e67-e73. DOI: 10.1097/TP. 0000000000001978.
    [8] 中华医学会器官移植学分会. 上腹部多器官联合移植技术操作规范(2019版)[J]. 器官移植, 2019, 10(6): 638-652. DOI: 10.3969/j.issn.1674-7445.2019.06.003.

    Branch of Organ Transplantation of Chinese Medical Association. Technical operation specification for combined multiple organ transplantation in the upper abdomen (2019 edition)[J]. Organ Transplant, 2019, 10(6): 638-652. DOI: 10.3969/j.issn.1674-7445.2019.06.003.
    [9] 王深明, 崔进. 我国腹主动脉瘤的治疗现状[J]. 中国普外基础与临床杂志, 2017, 24(1): 1-3. DOI: 10.7507/ 1007-9424.201612088.

    WANG SM, CUI J. Current status of treatment of abdominal aortic aneurysm in China[J]. Chin J Bases Clin Gen Surg, 2017, 24(1): 1-3. DOI: 10.7507/1007-9424.201612088.
    [10] SRIRANGALINGAM U, GUNGANAH K, CARPENTER R, et al. Phaeochromocytoma and paraganglioma excision involving the great vessels[J]. EJVES Short Rep, 2017, 35: 1-6. DOI: 10.1016/j.ejvssr.2017.02.002.
    [11] 来志超, 孙晓宁, 古丽丹娜·沙艳, 等. 胸腹主动脉瘤的手术方式与外科治疗选择[J/CD]. 中国血管外科杂志(电子版), 2018, 10(4): 233-236.

    LAI ZC, SUN XN, GULIDANNA SY, et al. Options of surgical methods for thoracoabdominal aortic aneurysm[J/CD]. Chin J Vasc Surg (Electr Vers), 2018, 10(4): 233-236.
    [12] 俞颖, 金琳, 仓静, 等. 主动脉全弓置换术后严重并发症的危险因素[J]. 中华麻醉学杂志, 2018, 38(2): 142-145. DOI: 10.3760/cma.j.issn.0254-1416.2018.02.004.

    YU Y, JIN L, CANG J, et al. Risk factors for severe complications after total aortic arch replacement[J]. Chin J Anesthesiol, 2018, 38(2): 142-145. DOI: 10.3760/cma.j.issn.0254-1416.2018.02.004.
    [13] LIU SQ, LEI P, CUI XH, et al. Sutureless anastomoses using magnetic rings in canine liver transplantation model[J]. J Surg Res, 2013, 185(2): 923-933. DOI: 10.1016/j.jss.2013.07.025.
    [14] 史源, 杨涛, 张全胜, 等. 磁环法快速重建肝上下腔静脉大鼠肝移植模型[J/CD]. 实用器官移植电子杂志, 2016, 4(2): 79-82. DOI: 10.3969/j.issn.2095-5332.2016.02.005.

    SHI Y, YANG T, ZHANG QS, et al. Magnetic ring anastomosis of supra-hepatic vena cava: a novel technique for liver transplantation in rat[J/CD]. Prac J Organ Transplant(Electr Vers), 2016, 4(2): 79-82. DOI: 10.3969/j.issn.2095-5332.2016.02.005.
    [15] 杨丽斐, 吕毅. 磁吻合技术实现无缝线肝脏快速植入的临床前研究[J]. 器官移植, 2017, 8(3): 181-185. DOI: 10.3969/j.issn.l674-7445.2017.03.001.

    YANG LF, LYU Y. Pre-clinical study of suture-free rapid liver implantation by the magnetic anastomosis technique[J]. Organ Transplant, 2017, 8(3): 181-185. DOI: 10.3969/j.issn.l674-7445.2017.03.001.
    [16] 杨丽斐, 陆建文, 史源, 等. 磁压榨吻合技术在大鼠肝移植模型建立中的应用[J/CD]. 中华肝脏外科手术学电子杂志, 2017, 6(5): 410-414. DOI: 10.3877/cma.j.issn.2095-3232.2017.05.017.

    YANG LF, LU JW, SHI Y, et al. Application of magnetic compression anastomosis in establishment of rat models of liver transplantation[J/CD]. Chin J Hepat Surg(Electr Edit), 2017, 6(5): 410-414. DOI: 10.3877/cma.j.issn.2095-3232.2017.05.017.
    [17] LU Q, LIU K, ZHANG W, et al. End-to-end vascular anastomosis using a novel magnetic compression device in rabbits: a preliminary study[J]. Sci Rep, 2020, 10(1): 5981. DOI: 10.1038/s41598-020-62936-6.
    [18] 刘仕琪, 吕毅, 赵静儒, 等. 磁吻合技术治疗先天性食管闭锁与狭窄的临床疗效[J]. 中华消化外科杂志, 2019, 18(6): 581-586. DOI:10.3760/cma.j.issn.1673-9752. 2019.06.013.

    LIU SQ, LYU Y, ZHAO JR, et al. Clinical efficacy of magnetic compression anastomosis for congenital esophageal atresia and stenosis[J]. Chin J Dig Surg, 2019, 18(6): 581-586. DOI: 10.3760/cma.j.issn.1673-9752.2019.06.013.
    [19] 刘仕琪, 吕毅, 赵静儒, 等. 内镜下磁吻合术治疗先天性食管狭窄一例[J]. 中华消化内镜杂志, 2020, 37(8): 596-597. DOI: 10.3760/cma.j.cn321463-20191221-00341.

    LIU SQ, LYU Y, ZHAO JR, et al. A case of congenital esophageal stricture treated by magnetic anastomosis under endoscope[J]. Chin J Dig Endosc, 2020, 37(8): 596-597. DOI: 10.3760/cma.j.cn321463-20191221-00341.
    [20] 刘仕琪, 赵静儒, 高亚, 等. 磁吻合技术在小儿外科领域中的应用[J]. 科学通报, 2020, 65(13): 1264-1273. DOI: 10.1360/TB-2019-0881.

    LIU SQ, ZHAO JR, GAO Y, et al. Application of magnetic compression anastomosis technique in pediatric surgery[J]. Chin Sci Bull, 2020, 65(13): 1264-1273. DOI: 10.1360/TB-2019-0881.
    [21] MARTINO CF, PEREA H, HOPFNER U, et al. Effects of weak static magnetic fields on endothelial cells[J]. Bioelectromagnetics, 2010, 31(4): 296-301. DOI: 10.1002/bem.20565.
    [22] NAARALA J, KESARI KK, MCCLURE I, et al. Direction-dependent effects of combined static and ELF magnetic fields on cell proliferation and superoxide radical production[J]. Biomed Res Int, 2017: 5675086. DOI: 10.1155/2017/5675086.
    [23] 朱一鸣, 方彦雯, 杨建成, 等. 磁场与血管生成研究进展[J]. 科学通报, 2020, 65(13): 1224-1237. DOI: 10.1360/TB-2019-0883.

    ZHU YM, FANG YW, YANG JC, et al. Magnetic fields and angiogenesis[J]. Chin Sci Bull, 2020, 65(13): 1224-1237. DOI: 10.1360/TB-2019-0883.
    [24] LI Q, LIAO Z, GU L, et al. Moderate intensity static magnetic fields prevent thrombus formation in rats and mice[J]. Bioelectromagnetics, 2020, 41(1): 52-62. DOI: 10.1002/bem.22232.
    [25] 张欣. 稳态磁场对血流、骨骼和疼痛的影响[J]. 物理, 2020, 49(6): 373-380. DOI: 10.7693/wl20200603.

    ZHANG X. Effects of static magnetic fields on blood flow, bone and pain[J]. Physics, 2020, 49(6): 373-380. DOI: 10.7693/wl20200603.
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出版历程
  • 收稿日期:  2020-10-22
  • 网络出版日期:  2021-03-19
  • 刊出日期:  2021-03-15

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