调节性免疫细胞在异种移植免疫中的作用

石炳毅; 陈文; 刘志佳

doi:10.3969/j.issn.1674-7445.2020.03.001

调节性免疫细胞在异种移植免疫中的作用

doi: 10.3969/j.issn.1674-7445.2020.03.001

100091 北京, 中国人民解放军总医院第八医学中心全军器官移植研究所

基金项目:

国家自然科学基金 81570680

国家自然科学基金 81571555

详细信息

作者简介:
石炳毅, 主任医师、教授、博士生导师, 第十届全国政协委员, 获国务院政府特殊津贴、何梁何利科技进步奖和中国医师奖。现任中国人民解放军总医院第八医学中心全军器官移植研究所名誉所长、北京市器官移植与免疫调节重点实验室主任, 兼任中国人体器官捐献与移植委员会委员、国家级肾脏移植质控中心主任、中华医学会器官移植学分会主任委员、中国研究型医院学会移植医学专业委员会主任委员等学术职务。长期从事泌尿外科和器官移植的临床与科研工作, 构建国家级肾移植数据平台和质控中心, 主持制定器官移植相关行业标准, 为推动我国器官移植事业的规范化进程做出了突出贡献。先后承担国家 863 课题、科技支撑重大项目、国家自然科学基金课题 20 余项。以第一完成人获国家科技进步二等奖 1 项, 中华医学科技一等奖 2 项, 军队(省部级)科技进步和医疗成果一、二等奖 5 项, 国家发明专利 6 项。主编国内行业标准《临床诊疗指南》和《临床技术操作规范》器官移植分册等专著 9 部, 发表论文 330 余篇, 其中 SCI 收录 51 篇, 培养博士(后)、硕士研究生72人

通讯作者:
石炳毅，Email：shibingyi666@126.com

中图分类号: R617, R392.4
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- 被引次数: 0
出版历程
- 收稿日期: 2020-02-18
- 网络出版日期: 2021-01-19
- 刊出日期: 2020-05-15

The function of regulatory immunological cell in xenotransplantation immunity

Organ Transplantation Institute of the 8th Medical Center of Chinese People s Liberation Army General Hospital, Beijing 100091, China

More Information

Corresponding author: Shi Bingyi,Email:shibingyi666@126.com

摘要

摘要: 异种移植是未来解决器官短缺最有前景的方法。近年来基因编辑和免疫学技术的进步推动了异种移植的快速发展, 但是异种移植的临床应用仍然存在诸多难以克服的障碍, 其中排斥反应是引起异种移植失败的最重要原因。调节性免疫细胞是机体内一群具有负性调节功能的免疫细胞, 能够抑制同种异体移植排斥反应, 延长移植物的存活时间。本文总结了近几年调节性免疫细胞在异种移植应用的研究进展, 为异种移植排斥反应预防和治疗提供参考。
- 调节性免疫细胞 /
- 异种移植 /
- 排斥反应 /
- 移植免疫 /
- 调节性 T 细胞(Treg) /
- 调节性树突状细胞(DCreg) /
- 滤泡调节性 T 细胞(Tfr) /
- 调节性 B 细胞(Breg)
Abstract: Xenotransplantation is the most promising method to resolve the organ shortage problem in the future. In recent years, the advances in gene editing and immunological technique have driven the rapid development of xenotransplantation. However, there are still many insurmountable obstacles in the clinical application of xenotransplantation, among which the rejection is the most important cause of the xenotransplantation failure. Regulatory immunological cells are a group of immunological cells with the negative regulation function in the body, which can inhibit allotransplantation rejection and prolong the survival time of the graft. This paper summarized the research progress of regulatory immunological cells in the xenotransplantation application in recent years, providing reference for the prevention and treatment of xenotransplantation rejection.
- Regulatory immunological cell /
- Xenotransplantation /
- Rejection /
- Transplantation immunity /
- Regulatory T cell (Treg) /
- Regulatory dendritic cell (DCreg) /
- Follicular regulatory T cell (Tfr) /
- Regulatory B cell (Breg)

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参考文献(27)

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