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分泌颗粒酶B的调节性B细胞在器官移植术后免疫调节作用的研究进展

刘子希 李先亮 贺强 朱继巧

刘子希, 李先亮, 贺强, 等. 分泌颗粒酶B的调节性B细胞在器官移植术后免疫调节作用的研究进展[J]. 器官移植, 2019, 10(6): 724-726, 734. doi: 10.3969/j.issn.1674-7445.2019.06.016
引用本文: 刘子希, 李先亮, 贺强, 等. 分泌颗粒酶B的调节性B细胞在器官移植术后免疫调节作用的研究进展[J]. 器官移植, 2019, 10(6): 724-726, 734. doi: 10.3969/j.issn.1674-7445.2019.06.016
Liu Zixi, Li Xianliang, He Qiang, et al. Research progress of regulatory B cell secreting granzyme B in immunoregulation after organ transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(6): 724-726, 734. doi: 10.3969/j.issn.1674-7445.2019.06.016
Citation: Liu Zixi, Li Xianliang, He Qiang, et al. Research progress of regulatory B cell secreting granzyme B in immunoregulation after organ transplantation[J]. ORGAN TRANSPLANTATION, 2019, 10(6): 724-726, 734. doi: 10.3969/j.issn.1674-7445.2019.06.016

分泌颗粒酶B的调节性B细胞在器官移植术后免疫调节作用的研究进展

doi: 10.3969/j.issn.1674-7445.2019.06.016
基金项目: 

国家自然科学基金 81601392

移植耐受与器官保护北京市重点实验室开放课题 2017YZNS01

详细信息
    作者简介:

    刘子希,男,1994年生,硕士研究生,研究方向为肝移植,Email:13381166278@163.com

    通讯作者:

    贺强,男,1964年生,博士,主任医师,研究方向为肝移植与肝胆胰恶性肿瘤,Email:heqiang349@sina.com

    朱继巧,男,1981年生,博士,副主任医师,研究方向为肝移植,Email:dr_zhujiqiao@163.com

  • 中图分类号: R617, R392.4

Research progress of regulatory B cell secreting granzyme B in immunoregulation after organ transplantation

  • 摘要: 器官移植术后的排斥反应以及长期使用免疫抑制所致的代谢性疾病、肾功能不全、感染、肿瘤复发等并发症,严重影响着受者的长期生存和生活质量。因此,诱导器官移植术后免疫耐受是移植科医师所追求的最终目标。目前研究发现,调节性B细胞(Breg)在移植术后免疫耐受的形成中发挥了重要作用。本文主要从分泌颗粒酶B(GrB)的Breg(GrB+Breg)的发现和特点、GrB发挥免疫调节作用的方式、GrB+Breg在器官移植术后的免疫调节作用以及常用免疫抑制剂对GrB+Breg的作用进行文献综述。

     

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出版历程
  • 收稿日期:  2019-08-02
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2019-11-15

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