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肾移植免疫抑制剂研究进展

马锡慧 肖漓

马锡慧, 肖漓. 肾移植免疫抑制剂研究进展[J]. 器官移植, 2019, 10(4): 459-464. doi: 10.3969/j.issn.1674-7445.2019.04.019
引用本文: 马锡慧, 肖漓. 肾移植免疫抑制剂研究进展[J]. 器官移植, 2019, 10(4): 459-464. doi: 10.3969/j.issn.1674-7445.2019.04.019

肾移植免疫抑制剂研究进展

doi: 10.3969/j.issn.1674-7445.2019.04.019
基金项目: 

国家自然科学基金 81571555

解放军第309医院面上课题 2016MS-002

详细信息
    作者简介:

    马锡慧,女,1985年生,硕士,主管技师,研究方向为移植免疫基础与应用,Email:maxihui@sina.com

    通讯作者:

    肖漓,女,1972年生,博士,主任技师,研究方向为移植免疫基础与应用,Email:xiaolilab309@163.com

  • 中图分类号: R617

  • 摘要: 肾移植是终末期肾病的有效替代治疗方法,新型免疫抑制剂的应用极大提高了肾移植受者的存活率。新型免疫抑制剂的广泛应用促进了免疫抑制方案的改善和优化,术后急性排斥反应发生率不断降低和移植物短期存活率不断提高验证了免疫抑制剂发展的巨大成功。然而,其伴随的不良反应也逐渐显现。如何正确、高效、合理地应用免疫抑制剂是临床医师面临的新挑战。现从以T淋巴细胞为靶点的免疫抑制剂、以B淋巴细胞为靶点的免疫抑制剂、以补体为靶点的免疫抑制剂、以细胞因子为靶点的免疫抑制剂、以混合多克隆抗体为靶点的免疫抑制剂以及以多种细胞为靶点的免疫抑制剂的种类及机制等做一综述,从而为免疫抑制剂的选择应用提供理论基础。

     

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出版历程
  • 收稿日期:  2019-04-06
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2019-07-15

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