机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来？

谭晓宇; 陈晓兰; 林金铭; 梁佩乔; 刘宝棋; 欧阳青; 霍枫

doi:10.3969/j.issn.1674-7445.2019.04.018

机械灌注技术引领器官捐献与移植模式的变革——器官ICU时代即将到来？

doi: 10.3969/j.issn.1674-7445.2019.04.018

510010 广州，中国人民解放军南部战区总医院肝胆外科暨肝移植中心（谭晓宇、欧阳青、霍枫）；南方医科大学第一临床医学院（陈晓兰、林金铭、梁佩乔、刘宝棋）

基金项目:

国家青年科学基金项目 81800556

军队实验动物专项科研项目 SYDW(2017)12

详细信息

作者简介:
谭晓宇，男，1980年生，博士，主治医师，研究方向为肝移植、器官捐献与维护，Email：dr.tanxiaoyu@hotmail.com

通讯作者:
霍枫，男，1961年生，硕士，主任医师，研究方向为肝移植、器官捐献与维护，Email：gzhuofeng@163.com

中图分类号: R617
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- PDF下载量: 29
- 被引次数: 0
出版历程
- 收稿日期: 2019-04-07
- 网络出版日期: 2021-01-19
- 刊出日期: 2019-07-15

摘要

摘要: 机械灌注（MP）技术是器官移植领域的全球研究热点之一，近年的探索成果显示出其在器官保存、器官活力评估、修复受损器官中的优异性，将引领器官捐献与移植模式的变革。本文就近期MP技术在提升器官保存效果、评估器官活力、修复器官以及进行干预性治疗等方面的研究进展进行综述，并讨论未来临床应用的潜在模式。
- 机械灌注 /
- 器官捐献 /
- 器官移植 /
- 器官重症监护室 /
- 器官保存 /
- 边缘供体 /
- 器官修复

HTML全文

图 1 离体肝脏灌注设备（第5代）

Figure 1. Isolated hepatic perfusion equipment (the fifth generation)

下载: 全尺寸图片幻灯片

图 2 动物离体肝脏的HMP和NMP实验

Figure 2. HMP and NMP experiment of isolated liver of animal

下载: 全尺寸图片幻灯片

图 3 废弃人供肝HMP和NMP实验

Figure 3. HMP and NMP experiment of abandoned human donor liver

下载: 全尺寸图片幻灯片

图 4 器官ICU的新型管理模式流程

Figure 4. New management model flow of organ ICU

下载: 全尺寸图片幻灯片

表 1 NMP支持下成功移植的供肝灌注指标^[27]

Table 1. Perfusion indicators of successful liver transplantation supported by NMP

指标	具体内容
血流动力学参数	肝动脉流量（280±120）mL/min 门静脉流量（1 110±200）mL/min
代谢参数	pH值7.31±0.17 灌注15 min时乳酸（9.99±3.13）mmol/L 灌注4 h后乳酸（0.93±0.63）mmol/L
胆汁生成量	（9.17±11.16）mL/h

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表 2 器官ICU与ICU的特点

Table 2. Features of organ ICU and ICU

分类	器官ICU特点	ICU特点
功能	评估器官质量	危重症患者的评估
	器官功能维持	危重症患者器官功能维护
	修复器官功能	危重症患者救治
收治对象	边缘器官和高风险器官	危重症患者
管理形式	MP设备	ICU

下载: 导出CSV

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