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吗替麦考酚酯与麦考酚钠肠溶片对肾移植受体血药浓度的影响

曾维胜 张长升 宋秘 祝敏 李同海 李珍

曾维胜, 张长升, 宋秘, 等. 吗替麦考酚酯与麦考酚钠肠溶片对肾移植受体血药浓度的影响[J]. 器官移植, 2018, 9(6): 436-440. doi: 10.3969/j.issn.1674-7445.2018.06.007
引用本文: 曾维胜, 张长升, 宋秘, 等. 吗替麦考酚酯与麦考酚钠肠溶片对肾移植受体血药浓度的影响[J]. 器官移植, 2018, 9(6): 436-440. doi: 10.3969/j.issn.1674-7445.2018.06.007
Zeng Weisheng, Zhang Changsheng, Song Mi, et al. Effect of mycophenolate mofetil and enteric-coated mycophenolate sodium on blood concentration in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2018, 9(6): 436-440. doi: 10.3969/j.issn.1674-7445.2018.06.007
Citation: Zeng Weisheng, Zhang Changsheng, Song Mi, et al. Effect of mycophenolate mofetil and enteric-coated mycophenolate sodium on blood concentration in renal transplant recipients[J]. ORGAN TRANSPLANTATION, 2018, 9(6): 436-440. doi: 10.3969/j.issn.1674-7445.2018.06.007

吗替麦考酚酯与麦考酚钠肠溶片对肾移植受体血药浓度的影响

doi: 10.3969/j.issn.1674-7445.2018.06.007
基金项目: 

云南省科技厅-昆明医科大学应用基础研究联合专项资金项目 2017FE467(-036)

详细信息
    作者简介:

    曾维胜,男,1990年生,硕士研究生,研究方向为器官移植,Email:1445356997@qq.com

    通讯作者:

    李珍,女,1983年生,硕士,主管护师,研究方向为外科护理,Email:24225695@qq.com

  • 中图分类号: R617, R692.5

Effect of mycophenolate mofetil and enteric-coated mycophenolate sodium on blood concentration in renal transplant recipients

More Information
  • 摘要:   目的  探讨吗替麦考酚酯(MMF)与麦考酚钠肠溶片(EC-MPS)在同等生物效应剂量下对肾移植受体麦考酚酸(MPA)血药浓度和不良反应的影响。  方法  回顾性分析106例活体供肾移植受体的临床资料。按肾移植术后服用不同药物分为两组,MMF组(M1组,62例)和EC-MPS组(M2组,44例)。两组受体的免疫抑制方案分别为M1组用他克莫司(FK506)+MMF+泼尼松,M2组用FK506+EC-MPS+泼尼松。分析两组受体服药后1、2、3周和1、2、3个月MPA血药浓度的变化情况、不良反应发生情况及服用药物所花费用。  结果  采取同等生物效应给药,服药后第1、2、3周,第1、2、3个月时M1组MPA血药谷浓度比M2组低,各个时间点两组间比较,差异均有统计学意义(均为P < 0.05)。与M1组比较,M2组术后不良反应的发生率较低且症状较轻。采用同等生物学效应给药,M1组服用MMF所花费用1 710元/月,M2组服用EC-MPS所花费用2 736元/月,但M1组因治疗药物不良反应所产生费用远高于M2组。  结论  同等的生物效应剂量下服用EC-MPS的患者相对服用MMF的患者能维持更高的MPA血药浓度并且不良反应更少。

     

  • 图  1  两组受体服药后MPA血药谷浓度的比较

    Figure  1.  Comparison of trough serum concentrations of MPA of recipients between two groups after administration

    表  1  两组受体服药后不良反应发生情况

    Table  1.   The incidence of adverse events of recipients between the two groups after administration [n(%)]

    组别 n 重症肺部感染 中重度胃肠道症状 急性排斥反应 移植物失功 其他
    M1组 62 5(8) 9(15) 4(6) 1(2) 1(2)
    M2组 44 1(2) 2(5) 1(2) 0 1(2)
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出版历程
  • 收稿日期:  2018-08-21
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-11-15

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