人类白细胞抗原-G在临床医学中的研究进展

李圣冰; 肖漓

doi:10.3969/j.issn.1674-7445.2018.05.004

人类白细胞抗原-G在临床医学中的研究进展

doi: 10.3969/j.issn.1674-7445.2018.05.004

李圣冰,
肖漓^,

075000　张家口，河北北方学院（李圣冰）；中国人民解放军第 309 医院移植研究室（肖漓）

基金项目:

国家自然科学基金 81571555

详细信息

作者简介:
李圣冰，女，1996年生，硕士研究生，研究方向为病原生物学，Email：15230006363@163.com

肖漓, 女, 主任技师, 博士, 免疫学专业, 硕士研究生导师。现任中国人民解放军第309医院移植研究室主任。主要从事器官移植免疫学的临床检测和科研工作。主持国家自然科学基金面上项目、首都卫生发展自主创新专项、首都特色临床医疗项目等多项课题。兼任中国免疫学移植免疫学委员、中华医学会器官移植专业委员会移植免疫学组委员、解放军医学科学技术委员会免疫学专业委员等。兼任《器官移植》杂志通讯编委。发表SCI及论著50余篇。主编、参编专著多部。参与完成获国家科技进步奖二等奖、中华医学科技奖一等奖、华夏科技进步奖一等奖的项目研究

通讯作者:
肖漓，女，1972年生，主任技师，研究方向为移植免疫学，Email：xiaolilab309@163.com

中图分类号: R617, R318.06
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- 文章访问数: 239
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- 被引次数: 0
出版历程
- 收稿日期: 2018-05-25
- 网络出版日期: 2021-01-19
- 刊出日期: 2018-09-15

Research progress on human leukocyte antigen-G in clinical medicine

Li Shengbing,
Xiao Li^,

摘要

摘要: 人类白细胞抗原(HLA)-G是一类非经典HLAⅠb类分子, 早期的研究主要集中在妊娠免疫, HLA-G可保护胎儿免受母体免疫系统的攻击。近几年越来越多的研究发现HLA-G在诱导器官移植物免疫耐受、协助肿瘤细胞以及病毒的免疫逃逸中发挥着重要作用。因此将HLA-G作为器官移植、恶性肿瘤和病毒感染等疾病诊断和治疗的靶点已逐渐成为学者关注的热点。本文就HLA-G的基因多态性与分子结构、HLA-G在临床医学中应用的最新进展做一总结。
- 人类白细胞抗原-G(HLA-G) /
- 器官移植 /
- 基因多态性 /
- 肿瘤 /
- 病毒感染 /
- 自身免疫性疾病 /
- 妊娠 /
- 免疫逃逸

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参考文献(35)

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