线粒体自噬在肾缺血-再灌注损伤中的作用

王天宇; 周江桥

doi:10.3969/j.issn.1674-7445.2018.03.014

线粒体自噬在肾缺血-再灌注损伤中的作用

doi: 10.3969/j.issn.1674-7445.2018.03.014

王天宇,
周江桥^,

430060 武汉大学人民医院器官移植科

基金项目:

国家自然科学基金青年基金项目 81400753

详细信息

作者简介:
王天宇，男，1993年生，住院医师，研究方向为肾缺血-再灌注机制，Email：403391473@qq.com

通讯作者:
周江桥，男，1965年生，博士，主任医师，研究方向为肾缺血-再灌注机制，Email：zhoujq@whu.edu.cn

中图分类号: R617
计量
- 文章访问数: 131
- HTML全文浏览量: 17
- PDF下载量: 12
- 被引次数: 0
出版历程
- 收稿日期: 2018-03-28
- 网络出版日期: 2021-01-19
- 刊出日期: 2018-05-15

摘要

摘要: 线粒体自噬是机体选择性清除受损线粒体的防御性过程，对维持细胞生存有重要意义。一般情况下线粒体自噬阈值较低，当处在能量耗竭、缺血、缺氧等环境中时，线粒体自噬可被激活。肾脏的缺血-再灌注损伤（IRI）是临床中较为常见的病理生理过程，是导致急性肾损伤的主要原因。目前认为IRI与氧化应激、线粒体功能紊乱、自噬和凋亡等密切相关。本文就线粒体自噬的概述、线粒体自噬在肾IRI中的作用以及线粒体自噬的调控进行综述，为临床中防治肾IRI提供新的研究思路。
- 肾脏 /
- 缺血-再灌注损伤（IRI） /
- 线粒体 /
- 自噬 /
- 氧化应激 /
- 调控

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参考文献(28)

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