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心脏死亡器官捐献扩展标准供体肾移植早期临床效果分析

阮东丽 张更 刘克普 李智斌 高龙 郑文峰 王会龙 袁建林

阮东丽, 张更, 刘克普, 等. 心脏死亡器官捐献扩展标准供体肾移植早期临床效果分析[J]. 器官移植, 2018, 9(3): 222-226. doi: 10.3969/j.issn.1674-7445.2018.03.010
引用本文: 阮东丽, 张更, 刘克普, 等. 心脏死亡器官捐献扩展标准供体肾移植早期临床效果分析[J]. 器官移植, 2018, 9(3): 222-226. doi: 10.3969/j.issn.1674-7445.2018.03.010
Ruan Dongli, Zhang Geng, Liu Kepu, et al. Analysis of early clinical efficacy of renal transplantation from extended criteria donor of the donation after cardiac death[J]. ORGAN TRANSPLANTATION, 2018, 9(3): 222-226. doi: 10.3969/j.issn.1674-7445.2018.03.010
Citation: Ruan Dongli, Zhang Geng, Liu Kepu, et al. Analysis of early clinical efficacy of renal transplantation from extended criteria donor of the donation after cardiac death[J]. ORGAN TRANSPLANTATION, 2018, 9(3): 222-226. doi: 10.3969/j.issn.1674-7445.2018.03.010

心脏死亡器官捐献扩展标准供体肾移植早期临床效果分析

doi: 10.3969/j.issn.1674-7445.2018.03.010
详细信息
    作者简介:

    阮东丽,女,1984年生,硕士,主治医师,研究方向为肾移植,Email:745501416@qq.com

    通讯作者:

    袁建林,男,1964年生,博士,主任医师,研究方向为器官移植,Email:jianliny@fmmu.edu.cn

  • 中图分类号: R617, R619

Analysis of early clinical efficacy of renal transplantation from extended criteria donor of the donation after cardiac death

More Information
  • 摘要:   目的  比较扩展标准供体(ECD)及标准供体(SCD)肾移植的早期临床效果。  方法  回顾性分析接受心脏死亡器官捐献(DCD)供肾肾移植的85例受体临床资料。根据供体类型,将相应受体分为ECD组(31例)和SCD组(54例)。比较两组受体肾移植术后3个月内血清肌酐(Scr)水平、早期并发症发生情况及预后情况。  结果  ECD组和SCD组术后1个月内的Scr水平差异无统计学意义(均为P > 0.05),ECD组术后60、90 d的Scr水平分别为(189±97)、(175±69)μmol/L,明显高于SCD组的(142±49)、(135±41)μmol/L(P=0.005,0.002)。ECD组和SCD组的急性排斥反应(AR)发生率分别为6%和15%,移植物功能延迟恢复(DGF)发生率分别为23%和19%,肺部感染发生率分别为10%和6%,其他早期并发症发生率分别为32%和15%,差异均无统计学意义(均为P > 0.05)。ECD组和SCD组人存活率分别为97%和94%,ECD组和SCD组肾存活率分别为84%和91%,差异均无统计学意义(均为P > 0.05)。  结论  与SCD相比,ECD肾移植亦可获得相当的早期临床效果。在目前供肾来源严重缺乏的条件下,ECD的使用可以扩大供肾来源。

     

  • 图  1  两组受体肾移植术后3个月内Scr水平比较

    Figure  1.  Comparison of Scr levels of recipients between two groups within 3 months after renal transplantation

    表  1  两组受体肾移植术后早期并发症发生率的比较

    Table  1.   Comparison of the incidences of early complications in recipients between two groups after renal transplantation[n(%)]

    组  别 n AR DGF 肺部感染 其他
    ECD组 31 2(6)0 7(23) 3(10) 10(32)
    SCD组 54 8(15) 10(19). 3(6)0 08(15)
    χ2   1.363 0.203 0.510 3.590
    P   0.238 0.652 0.476 0.057
    其他并发症包括泌尿系感染、上呼吸道感染、移植肾周血肿、移植肾血栓、移植肾真菌感染、移植肾输尿管结石、髂外动脉假性动脉瘤、漏尿等
    下载: 导出CSV
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出版历程
  • 收稿日期:  2018-02-15
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2018-05-15

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