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摘要: 细胞、组织及器官移植是治疗器官功能衰竭、癌症等重大疾病直接有效的治疗策略。免疫排斥是同种及异种移植研究领域中难以彻底攻克的难题,因此对移植受体免疫排斥反应的实时监测尤为重要,针对同种及异种移植开发具有特异度高、早期灵敏度高、非侵入、快速等优点的生物标志物及其监测方法非常迫切。微小核糖核酸(miRNA)在免疫细胞的生成、发育以及免疫性功能中发挥重要的作用。本文对常规免疫排斥监测方法的局限性、miRNA的生物学特性以及miRNA在同种和异种移植免疫排斥中的应用进行总结,以探讨miRNA在同种和异种移植免疫排斥监测中的应用前景。
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