MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景

林善; 陆赢; 蔡志明; 戴一凡; 牟丽莎

doi:10.3969/j.issn.1674-7445.2018.03.001

MicroRNA在同种及异种移植免疫排斥监测中的研究进展及应用前景

doi: 10.3969/j.issn.1674-7445.2018.03.001

510275 广州，中山大学（林善、陆赢、牟丽莎）；深圳市第二人民医院（林善、陆赢、蔡志明、牟丽莎）；南京医科大学（戴一凡）

基金项目:

国家重点研发计划 2017YFC1103704

深圳市医疗卫生三名工程 SZSM201412020

深圳市高水平医学学科建设专项基金 2016031638

深圳市科技计划 JCJY20160229204849975

深圳市科技计划 GJHZ20170314171357556

深圳市卫生计生系统科研项目 SZXJ2017021

详细信息

作者简介:
林善，男，1989年生，博士，助理研究员，研究方向为异种胰岛移植，Email：biotechlin@foxmail.com

蔡志明，主任医师、教授、博士研究生导师。现任深圳大学泌尿生殖研究所所长，国家泌尿生殖肿瘤中心副主任，国家地方联合肿瘤工程实验室主任，广东省泌尿生殖肿瘤重点实验室主任，国家“973”计划首席科学家，教育部“长江学者计划”、中共中央组织部“千人计划”等高层次人才评审专家，享受国务院特殊津贴。作为负责人先后承担国家“973”计划、“863”计划、国家自然科学基金、博士点基金等研究项目15项；发表SCI论文170多篇，总影响因子超过1 100分，他引频次超过6 500次，在《Nature》、《Nature Genetics》、《Nature Biotechnology》和《Cell》等国际著名刊物发表论文7篇；出版著作4部，获得国家、省、市奖项9项；培养硕士、博士（后）100多名。获全国先进工作者、全国优秀院长、深圳市科技奖市长奖等荣誉称号

通讯作者:
蔡志明，男，1956年生，博士，主任医师，研究方向为异种胰岛移植，Email：caizhiming2000@163.com

牟丽莎，女，1983年生，博士，副研究员，研究方向为异种胰岛移植，Email：molly__molly@163.com

中图分类号: R617, R392.4
计量
- 文章访问数: 67
- HTML全文浏览量: 46
- PDF下载量: 14
- 被引次数: 0
出版历程
- 收稿日期: 2018-03-22
- 网络出版日期: 2021-01-19
- 刊出日期: 2018-05-15

摘要

摘要: 细胞、组织及器官移植是治疗器官功能衰竭、癌症等重大疾病直接有效的治疗策略。免疫排斥是同种及异种移植研究领域中难以彻底攻克的难题，因此对移植受体免疫排斥反应的实时监测尤为重要，针对同种及异种移植开发具有特异度高、早期灵敏度高、非侵入、快速等优点的生物标志物及其监测方法非常迫切。微小核糖核酸（miRNA）在免疫细胞的生成、发育以及免疫性功能中发挥重要的作用。本文对常规免疫排斥监测方法的局限性、miRNA的生物学特性以及miRNA在同种和异种移植免疫排斥中的应用进行总结，以探讨miRNA在同种和异种移植免疫排斥监测中的应用前景。
- 同种移植 /
- 异种移植 /
- 器官功能衰竭 /
- 免疫排斥 /
- 生物标志物 /
- 微小核糖核酸（miRNA） /
- 免疫细胞

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参考文献(35)

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