Visualization analysis on research trends and highlight frontiers in the field of pediatric liver transplantation from 2012 to 2016
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摘要:
目的 探讨近5年儿童肝移植国际研究动态与热点前沿。 方法 以Web of Science核心库中的英文文献为数据源，采用CiteSpace软件可视化分析儿童肝移植领域近5年的核心力量、作者、期刊、学科知识基础、热点及前沿。 结果 1 547条文献数据显示，美国是主要的发文量国家，占总发文量的25%；高发文量机构为日本国家儿童健康和发展中心，发文41篇；高产作者Kasahara M发文39篇，同时也是高被引作者；共形成两大作者合作群体；期刊《Pediatr Transplant》刊载该领域论文236篇，高被引期刊《Liver Transpl》被引频次达966次；近5年的学科知识基础研究集中在儿童肝移植的适应证、影响因素、术后并发症、存活率、健康状况等方面；高频关键词包括liver transplantation、children、recipients、experience、survival、outcomes等；高突变主题词包括orthotopic-liver-transplantation、high-risk、graft-function等。 结论 儿童肝移植近5年的研究热点包括肝移植的手术适应证，尤其是胆道闭锁、术后存活率与预后、术后并发症及风险因素、儿童肝移植管理与经验等研究。研究前沿集中在原位肝移植、术后随访与管理、防治血管并发症及危险因素、儿童活体肝移植、术前评估及术后肝功能研究等方面。 -
图 1 儿童肝移植研究国家(地区)分布知识图谱
Figure 1. Knowledge map of countries (regions) distribution for pediatric liver transplantation
图 2 儿童肝移植研究机构分布知识图谱
Figure 2. Knowledge map of institution distribution for pediatric liver transplantation
图 3 儿童肝移植领域作者合作网络知识图谱
Figure 3. Knowledge map of author cooperation in pediatric liver transplantation
图 4 儿童肝移植领域共被引期刊知识图谱
Figure 4. Knowledge map of journal co-citation in pediatric liver transplantation
图 5 儿童肝移植突变主题词变化时区图谱
Figure 5. Time zone map of the change of burst terms in pediatric liver transplantation
图 6 儿童肝移植领域突变词权重分布图
Figure 6. The weight distribution of burst terms in pediatric liver transplantation
表 1 儿童肝移植研究发文量排名前10名的机构
Table 1. Top 10 institutions for pediatric liver transplantation research
序号 机构名称(英文) 机构名称(中文) 发文量（篇） 国家 1 Natl Ctr Child Hlth & Dev 国家儿童健康和发展中心 41 日本 2 Jichi Med Univ 自治医科大学 37 日本 3 Univ Pittsburgh 匹兹堡大学 28 美国 4 Univ Ulsan 蔚山大学 25 韩国 5 Baskent Univ 巴什肯特大学 25 土耳其 6 Shanghai Jiao Tong Univ 上海交通大学 23 中国 7 Univ Calif San Francisco 加州大学旧金山分校 22 美国 8 Shiraz Univ Med Sci 设拉子医科大学 22 伊朗 9 Univ Sao Paulo 圣保罗大学 19 巴西 10 Sungkyunkwan Univ 成均馆大学 19 韩国 
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表 2 儿童肝移植领域的高被引频次作者
Table 2. Authors with high cited frequency in pediatric liver transplantation
序号 高被引作者 被引频次（次） 1 Kasahara M 103 2 Mcdiarmid SV 101 3 StarzL TE 88 4 Mazzaferro V 85 5 Ng VL 84 6 Bruix J 70 7 Otte JB 69 8 Llovet JM 57 9 Egawa H 56 10 Alonso EM 54
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表 3 儿童肝移植领域的高中心性作者
Table 3. Authors with high centrality in pediatric liver transplantation
序号 高中心性作者 中心性 1 Otte JB 0.48 2 Bismuth H 0.25 3 Mcdiarmid SV 0.22 4 Kasahara M 0.22 5 Duffy JP 0.22 6 Davenport M 0.19 7 Ng VL 0.19 8 Broelsch CE 0.18 9 Mazzaferro V 0.18 10 Emre S 0.18
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表 4 儿童肝移植研究的高产期刊
Table 4. Journals with high publication for pediatric liver transplantation
序号 期刊名 发文量（篇） 影响因子 1 Pediatr Transplant 236 1.294 2 Transplant Proc 136 0.908 3 Liver Transpl 105 3.910 4 Exp Clin Transplant 53 0.535 5 Am J Transplant 52 6.165 6 J Pediatr Gastroenterol Nutr 47 2.799 7 World J Gastroenterol 35 3.365 8 Ann Transplant 33 1.252 9 Transplantation 29 3.678 10 J Pediatr Surg 28 1.976
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表 5 儿童肝移植领域共被引频次排名前5名的被引文献
Table 5. Top 5 references in terms of co-citation in pediatric liver transplantation
序号 发表年份 文献文题 作者 被引频次（次） 1 1996 Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis Mazzaferro V, et al 61 2 2008 Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American Multicenter Registry Ng VL, et al 44 3 2012 Health status of children alive 10 years after pediatric liver transplantation performed in the US and Canada: report of the studies of pediatric liver transplantation experience Ng VL, et al 41 4 2006 Progressive histological damage in liver allografts following pediatric liver transplantation Evans HM, et al 39 5 2001 A model to predict survival in patients with end-stage liver disease Kamath PS, et al 38
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表 6 儿童肝移植领域中心度排名前5名的被引文献
Table 6. Top 5 references in terms of centrality in pediatric liver transplantation
序号 发表年份 文献文题 作者 中心性 1 2007 Impact of graft type on outcome in pediatric liver transplantation:
a report from Studies of Pediatric Liver Transplantation (SPLIT)Diamond IR, et al 0.51 2 2011 A multivariate analysis of pre-, peri-, and post-transplant factors affecting outcome after pediatric liver transplantation Mcdiarmid SV, et al 0.45 3 2002 Development of a pediatric end-stage liver disease score to predict poor outcome in children awaiting liver transplantation Mcdiarmid SV, et al 0.33 4 2009 Pediatric liver transplantation Spada M, et al 0.29 5 2008 Outcomes of 5-year survivors of pediatric liver transplantation: report on 461 children from a North American Multicenter Registry Ng VL, et al 0.23
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表 7 儿童肝移植领域的高频关键词
Table 7. High frequency keywords in pediatric liver transplantation
序号 关键词 频次（次） 1 liver transplantation 519 2 children 503 3 recipients 257 4 experience 200 5 disease 175 6 survival 154 7 outcomes 149 8 cirrhosis 143 9 management 140 10 risk-factors 122 11 transplantation 118 12 complications 111 13 biliary atresia 94 14 impact 88
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