猪肺异种移植的研究进展与发展方向

周明; 邓阳阳; 戴一凡; 蔡志明; 牟丽莎

doi:10.3969/j.issn.1674-7445.2017.06.013

猪肺异种移植的研究进展与发展方向

doi: 10.3969/j.issn.1674-7445.2017.06.013

510275 广州，中山大学（周明、牟丽莎）；深圳市第二人民医院（周明、邓阳阳、蔡志明、牟丽莎）；南京医科大学（戴一凡）

基金项目:

国家自然科学基金青年基金 81601760

深圳市科创委学科布局项目 JCYJ20160229204849975

深圳市科创委企业工程中心项目 GCZX2015043017281705

高水平医学学科建设专项基金 2016031638

深圳市科技研发资金基础研究—自由探索 JCYJ20160425104534335

详细信息

通讯作者:
牟丽莎, Email: molly__molly@163.com

中图分类号: R617, R563
计量
- 文章访问数: 199
- HTML全文浏览量: 128
- PDF下载量: 17
- 被引次数: 0
出版历程
- 收稿日期: 2017-08-28
- 网络出版日期: 2021-01-19
- 刊出日期: 2017-11-15

摘要

摘要: 肺移植是治疗终末期肺疾病的唯一有效方法，但一直面临着严重的供体短缺问题。用猪肺替代人肺移植到人体内有望解决供体肺短缺的问题。但由于猪肺对多种损伤如组织灌注损伤、抗体依赖的补体损伤、适应性免疫反应以及凝血功能障碍造成的损伤等高度敏感，故而猪肺异种移植亦面临着许多难题亟待解决。本文介绍了目前异种肺移植的国内外研究现状，并归纳总结了异种肺移植的研究模型及其优缺点，着重论述了异种肺移植的损伤机制及可能的解决方案，并探讨了异种肺移植的未来发展方向。
- 异种移植 /
- 肺移植 /
- 猪 /
- 免疫排斥 /
- 凝血失调 /
- 基因敲除；CRISP/Cas9技术

HTML全文

图 1 肺离体灌注简易模型

空气流通管道连接到一个固定的气管上，血流从恒温37 ℃的容器经过蠕动泵流入肺动脉，血流从肺静脉流入储液器

Figure 1. Schematic presentation of the ex vivo lung perfusion model

下载: 全尺寸图片幻灯片

参考文献(26)

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