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肝移植术后渗透性脱髓鞘综合征的发病机制及诊疗进展

刘洪 阳敏 明英姿

刘洪, 阳敏, 明英姿. 肝移植术后渗透性脱髓鞘综合征的发病机制及诊疗进展[J]. 器官移植, 2017, 8(5): 402-405. doi: 10.3969/j.issn.1674-7445.2017.05.014
引用本文: 刘洪, 阳敏, 明英姿. 肝移植术后渗透性脱髓鞘综合征的发病机制及诊疗进展[J]. 器官移植, 2017, 8(5): 402-405. doi: 10.3969/j.issn.1674-7445.2017.05.014

肝移植术后渗透性脱髓鞘综合征的发病机制及诊疗进展

doi: 10.3969/j.issn.1674-7445.2017.05.014
基金项目: 

吴阶平医学基金会临床科研专项资助基金 320.6750.15070

详细信息
    通讯作者:

    明英姿, Email:myz_china@aliyun.com

  • 中图分类号: R617;R744.5

  • 摘要: 肝移植术后渗透性脱髓鞘综合征(ODS)是肝移植术后早期的严重并发症,其发生率为0.94%~3.00%。ODS的病理机制至今尚不清楚,目前认为与渗透压的快速改变相关。酗酒史、低钠血症的快速纠正和肝移植为ODS三大高危因素。临床表现常为脑病、癫痫发作及局部麻痹等,其预后一般较差。CT、MRI以及磁共振弥散加权成像(DWMRI)等结合临床病史可以早期诊断ODS。治疗上主要以对症治疗为主。此外,近年来血浆置换法和大量免疫球蛋白输注是ODS的新治疗方案,但疗效尚不明确。

     

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出版历程
  • 收稿日期:  2017-07-02
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2017-09-15

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