NK细胞亚群的研究进展及在移植免疫中的作用

孙曙; 蔡明; 刘志佳; 金海龙; 石炳毅

doi:10.3969/j.issn.1674-7445.2017.04.015

NK细胞亚群的研究进展及在移植免疫中的作用

doi: 10.3969/j.issn.1674-7445.2017.04.015

100091 北京, 解放军第309医院全军器官移植研究所泌尿外科

基金项目:

国家自然科学基金 81570680

详细信息

通讯作者:
石炳毅, Email：shibingyi@medmail.com.cn

中图分类号: R617, R392.4
计量
- 文章访问数: 440
- HTML全文浏览量: 254
- PDF下载量: 38
- 被引次数: 0
出版历程
- 收稿日期: 2017-04-15
- 网络出版日期: 2021-01-19
- 刊出日期: 2017-07-15

摘要

摘要: 自然杀伤（NK）细胞是机体免疫系统的重要组成部分, 在抗病毒感染免疫、肿瘤免疫、器官移植的排斥反应以及在免疫的调节中起着十分重要的作用。长期以来的研究表明, NK细胞并不是一个均一的细胞群体, 根据表面标志和功能的不同, 可以将NK细胞分为不同的亚群。在某些疾病的发生过程中, 如肿瘤、自身免疫性疾病等, 会导致NK细胞亚群的比例、表型改变和功能降低, 因此深入了解机体内NK细胞不同亚群的表型和功能特征, 从而明确其在疾病发生发展中的作用, 对揭示疾病的机制及早期发现疾病、判断预后、发现新的以NK细胞为靶点的免疫治疗措施, 具有重要意义。
- 自然杀伤细胞 /
- 器官移植 /
- 排斥反应 /
- 免疫耐受 /
- 免疫抑制剂 /
- 免疫治疗

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参考文献(20)

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