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肝移植术后过客淋巴细胞综合征的发病机制和研究进展

明英姿 庄权 成柯 赵于军 佘兴国 牛英 彭博 刘洪

明英姿, 庄权, 成柯, 等. 肝移植术后过客淋巴细胞综合征的发病机制和研究进展[J]. 器官移植, 2017, 8(4): 316-319. doi: 10.3969/j.issn.1674-7445.2017.04.014
引用本文: 明英姿, 庄权, 成柯, 等. 肝移植术后过客淋巴细胞综合征的发病机制和研究进展[J]. 器官移植, 2017, 8(4): 316-319. doi: 10.3969/j.issn.1674-7445.2017.04.014

肝移植术后过客淋巴细胞综合征的发病机制和研究进展

doi: 10.3969/j.issn.1674-7445.2017.04.014
基金项目: 

吴阶平医学基金会临床科研专项资助基金 320.6750.15070

湖南省自然科学基金平衡项目 2016JJ4105

详细信息
    通讯作者:

    刘洪, Email: hong804@sohu.com

  • 中图分类号: R617, R457.7

  • 摘要: 过客淋巴细胞综合征(PLS)是造血干细胞移植及实体器官移植术后常见的并发症, 也是造成移植术后溶血的主要原因。PLS是由于供者B细胞在移植后被输注到受者体内, 并被激活、增殖, 从而产生抗体, 导致溶血的发生。其主要发生在ABO或Rh血型不相合的移植中, 有时也可由某些不规则抗红细胞抗体所致。PLS可以通过血清学方法、嵌合体检测及流式细胞技术进行诊断。目前尚无可靠的方法治疗PLS, 但纠正贫血、去除抗体、抑制B细胞增殖及营养支持是治疗PLS的有效手段。

     

  • 表  1  肝移植术后PLS产生的不规则抗红细胞抗体案例总结

    Table  1.   The summary of irregular anti-red blood cell antibodies prodeuced by PLS after liver transplantation

    研究作者 年份 国别 受者年龄(岁) 性别 供者血型 受者血型 抗红细胞抗体
    Hyma BA, et al[18] 1988 美国 36 A+ O+ 抗Jka、抗c、抗S抗体
    Seltsam A, et al[19] 2001 德国 62 O+ O+ 抗K、抗Fya抗体
    Hareuveni M, et al[20] 2002 以色列 43 O+ O+ 抗Jka抗体
    Alexander SI, et al[21] 2008 澳大利亚 9 O- O+ 抗D抗体
    Makuria AT, et al[17] 2009 美国 44 A+ A+ 抗M抗体
    Koepsell SA, et al[22] 2013 美国 儿童 未提及 抗Kpb抗体
    Monfort M, et al[5] 2015 比利时 58 O+ A+ 抗D、抗C、抗E、抗K、抗Lea抗体
    Romero S, et al[16] 2015 西班牙 41 O- O+ 抗D抗体
    Romero S, et al[16] 2015 西班牙 49 A- A+ 抗D抗体
    下载: 导出CSV
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出版历程
  • 收稿日期:  2017-04-30
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2017-07-15

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