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肾移植术后丙型病毒性肝炎治愈1例:新型抗病毒药物的应用

邓庚国 申升 吴家清 周结学 李琴 朱春丽 蒙善东 马娟 刘东

邓庚国, 申升, 吴家清, 等. 肾移植术后丙型病毒性肝炎治愈1例:新型抗病毒药物的应用[J]. 器官移植, 2017, 8(3): 229-231. doi: 10.3969/j.issn.1674-7445.2017.03.011
引用本文: 邓庚国, 申升, 吴家清, 等. 肾移植术后丙型病毒性肝炎治愈1例:新型抗病毒药物的应用[J]. 器官移植, 2017, 8(3): 229-231. doi: 10.3969/j.issn.1674-7445.2017.03.011

肾移植术后丙型病毒性肝炎治愈1例:新型抗病毒药物的应用

doi: 10.3969/j.issn.1674-7445.2017.03.011
基金项目: 

广东省医学科研基金 B2016104

详细信息
    通讯作者:

    刘东,Email: Ld177@163.com

  • 中图分类号: R617, R512.6+3

  • 摘要:   目的   探讨以索非布韦为主的新型抗病毒药物治疗肾移植术后丙型病毒性肝炎(丙肝)的疗效与安全性。   方法   回顾性分析1例患有丙肝的二次肾移植受者应用索非布韦为主新方案治疗丙肝的诊疗过程,并进行经验总结。   结果   单用索非布韦方案治疗12周,随访至停药第12周复查发现该受体丙型肝炎病毒(HCV)RNA为5.82×104 IU/ml,未能实现持续病毒学应答(SVR)。采用索非布韦+雷迪帕韦+利巴韦林复合治疗方案后实现SVR。两种方案治疗期间患者均未出现不良反应,移植肾和肝功能良好。截至投稿日已术后1年余,患者肝、肾功能以及免疫抑制剂血药浓度稳定。   结论   单用索非布韦治疗肾移植术后丙肝疗效可能欠佳,复合治疗方案疗效相对稳定且安全。

     

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出版历程
  • 收稿日期:  2017-01-21
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2017-05-15

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