异种肝脏移植的历史与发展

陶开山; 李霄; 窦科峰

doi:10.3969/j.issn.1674-7445.2017.02.001

异种肝脏移植的历史与发展

doi: 10.3969/j.issn.1674-7445.2017.02.001

710032 西安，第四军医大学西京医院肝胆外科全军器官移植研究所

基金项目:

国家“973”计划基金资助项目 2015CB554100

国家“863”计划基金资助项目 2012AA021005

国家自然科学基金资助项目 81300361

国家自然科学基金资助项目 81270549

国家自然科学基金资助项目 81670593

国家自然科学基金资助项目 81470873

国家自然科学基金资助项目 81671838

西京医院学科助推计划基金资助项目 XJZT12M09

西京医院学科助推计划基金资助项目 XJZT13Z01

西京医院学科助推计划基金资助项目 XJZT14Z04

详细信息

作者简介:
陶开山，主任医师、教授、博士研究生导师。现任第四军医大学西京医院肝胆外科主任。长期在肝胆外科临床和科研一线工作，擅长肝胆胰脾肿瘤外科手术治疗和肝脏移植手术。开展了世界首例脾窝异位辅助性肝移植、世界首例劈裂式两人异位肝移植、世界首例脾窝异位辅助性肝移植联合肾移植术治疗高致敏性肾移植术后患者、世界首例α-1, 3-半乳糖苷转移酶基因敲除（GTKO）猪-藏酋猴异种脾窝异位辅助性肝移植、亚洲首例肝胰肾一期联合移植、亚洲首例心肝肾一期联合移植、国内首例活体肝移植、国内首例原位辅助性肝移植、国内最小年龄婴幼儿单肝段活体肝移植等创新性移植工作。多次在中央电视台、凤凰卫视、美国全国广播公司（NBC）和英国广播公司（BBC）等报道。兼任中国研究型医院学会普通外科学专业委员会副主任委员兼秘书长、中华医学会外科学分会外科手术学组委员、中华医学会肿瘤学分会肝癌学组委员、中国医师协会器官移植医师分会委员、中国医师协会外科医师分会肝脏外科医师委员会常务委员、中国研究型医院学会器官移植学专业委员会委员、全国抗癌协会肝癌专业委员会委员、全军器官移植学委员会副主任委员、全军普通外科学专业委员会秘书长、陕西省医学会器官移植委员会副主任委员；兼任《器官移植》、《中华肝胆外科杂志》等4本杂志编委。主持国家自然科学基金3项、陕西省重大项目1项等12项课题研究。共发表论著115篇，其中以第一作者和通讯作者在国外发表SCI论著32篇。主编专著1部、参编专著8部。中华医学科技奖一等奖1次、陕西省科技进步一等奖3次

通讯作者:
窦科峰，Email: doukef@fmmu.edu.cn

中图分类号: R617; R-332
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- 文章访问数: 271
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- PDF下载量: 24
- 被引次数: 0
出版历程
- 收稿日期: 2016-12-20
- 网络出版日期: 2021-01-19
- 刊出日期: 2017-03-15

摘要

摘要: 异种移植是解决同种供体器官短缺的重要途径。以α-1, 3-半乳糖苷转移酶基因敲除（GTKO）小型猪为供体、非人灵长类动物为受体的心脏和肾移植，最长存活达945 d和136 d，但肝移植尚无长期存活报道。国内外研究表明，免疫排斥和凝血调节障碍仍是阻碍移植肝和受体长期存活的主要原因。本文总结异种肝移植的发展历程，分析目前存在的问题，为未来的临床异种移植研究提供参考。
- 异种移植 /
- 肝脏 /
- 猪 /
- 基因修饰 /
- 非人灵长类动物 /
- α-1, 3-半乳糖苷转移酶

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参考文献(23)

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