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摘要: 肝窦毛细血管化是肝纤维化、肝硬化特征性的基础病理改变。我国作为肝炎大国,肝纤维化、肝硬化患者在肝脏疾病谱中占有很大比例。目前,肝窦毛细血管化形成的具体机制及其发生、发展影响因素仍不清楚。对肝窦毛细血管化形成原因、过程以及影响因素等方面进行研究,能为进一步揭示肝纤维化、肝硬化病理过程及阻断肝硬化病理进程提供理论依据,为肝纤维化、肝硬化的治疗提供新的视角。此外,晚期肝炎后肝硬化、顽固性腹腔积液、肝性脑病等终末期肝病多需肝移植治疗,肝窦毛细血管化研究可在一定程度上阻断终末期肝病的形成,有望缓解当下我国肝移植严峻形势所面临的压力。
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