Hippo信号通路与肝癌、肝脏缺血-再灌注损伤相互关系的研究进展

周熠; 李华

doi:10.3969/j.issn.1674-7445.2016.04.016

Hippo信号通路与肝癌、肝脏缺血-再灌注损伤相互关系的研究进展

doi: 10.3969/j.issn.1674-7445.2016.04.016

周熠,
李华^,

510630 广州，中山大学附属第三医院肝胆外科

基金项目:

国家自然科学基金 81172038

广东省自然科技基金 2014A020212484

详细信息

通讯作者:
李华，Email：lihua100@yeah.net

中图分类号: R617
计量
- 文章访问数: 57
- HTML全文浏览量: 55
- PDF下载量: 4
- 被引次数: 0
出版历程
- 收稿日期: 2016-04-13
- 网络出版日期: 2021-01-19
- 刊出日期: 2016-07-15

摘要

摘要: Hippo信号通路是在对果蝇的研究中被发现，在哺乳动物中高度保守，调节细胞生长、增殖和凋亡，进而控制器官大小的信号通路。近年来随着Hippo信号通路研究的快速进展，其与肝癌、肝脏缺血-再灌注损伤的相互关系逐步得到揭示，为防治肝癌发生、发展和肝脏缺血-再灌注损伤提供新的思路。但它们间的相互关系并未阐述清楚，本文就Hippo信号通路与肝癌、肝脏缺血-再灌注损伤相互关系的研究进展作一综述。
- Hippo信号通路 /
- YAP /
- 肝癌 /
- 缺血-再灌注损伤

HTML全文

参考文献(34)

[1]	Wu S, Huang J, Dong J, et al. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts[J]. Cell,2003,114(4):445-456. doi: 10.1016/S0092-8674(03)00549-X
[2]	Huang J, Wu S, Barrera J, et al. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP[J]. Cell,2005,122(3):421-434. doi: 10.1016/j.cell.2005.06.007
[3]	Plouffe SW, Hong AW, Guan KL. Disease implications of the Hippo/YAP pathway[J]. Trends Mol Med,2015,21(4):212-222. doi: 10.1016/j.molmed.2015.01.003
[4]	Yu FX, Zhao B, Guan KL. Hippo pathway in organ size control, tissue homeostasis, and cancer[J]. Cell,2015,163(4):811-828. doi: 10.1016/j.cell.2015.10.044
[5]	Varelas X. The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease[J]. Development,2014,141(8):1614-1626. doi: 10.1242/dev.102376
[6]	Zhang L, Yang S, Chen X, et al. The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells[J]. Mol Cell Biol,2015,35(8):1350-1362. doi: 10.1128/MCB.00102-15
[7]	Xu W, Wei Y, Wu S, et al. Up-regulation of the Hippo pathway effector TAZ renders lung adenocarcinoma cells harboring EGFR-T790M mutation resistant to gefitinib[J]. Cell Biosci,2015,5:7. doi: 10.1186/2045-3701-5-7
[8]	Oldani G, Crowe LA, Orci LA, et al. Pre-retrieval reperfusion decreases cancer recurrence after rat ischemic liver graft transplantation[J]. J Hepatol,2014,61(2):278-285. doi: 10.1016/j.jhep.2014.03.036
[9]	Nagai S, Yoshida A, Facciuto M, et al. Ischemia time impacts recurrence of hepatocellular carcinoma after liver transplantation[J]. Hepatology,2015,61(3):895-904. doi: 10.1002/hep.v61.3
[10]	Del Re DP, Yang Y, Nakano N, et al. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury[J]. J Biol Chem,2013,288(6):3977-3988. doi: 10.1074/jbc.M112.436311
[11]	Zhao S, Yin J, Zhou L, et al. Hippo/MST1 signaling mediates microglial activation following acute cerebral ischemia-reperfusion injury[J]. Brain Behav Immun,2016, 55:236-248. doi: 10.1016/j.bbi.2015.12.016
[12]	Barron DA, Kagey JD. The role of the Hippo pathway in human disease and tumorigenesis[J]. Clin Transl Med,2014,3:25. doi: 10.1186/2001-1326-3-25
[13]	Lai ZC, Wei X, Shimizu T, et al. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats[J]. Cell,2005,120(5):675-685. doi: 10.1016/j.cell.2004.12.036
[14]	Meng Z, Moroishi T, Guan KL. Mechanisms of Hippo pathway regulation[J]. Genes Dev,2016,30(1):1-17. doi: 10.1101/gad.274027.115
[15]	Qin F, Tian J, Zhou D, et al. Mst1 and Mst2 kinases: regulations and diseases[J]. Cell Biosci,2013,3(1):31. doi: 10.1186/2045-3701-3-31
[16]	Hoa L, Kulaberoglu Y, Gundogdu R, et al. The characterisation of LATS2 kinase regulation in Hippo-YAP signalling[J]. Cell Signal,2016,28(5):488-497. doi: 10.1016/j.cellsig.2016.02.012
[17]	Chen Q, Zhang N, Gray RS, et al. A temporal requirement for Hippo signaling in mammary gland differentiation, growth, and tumorigenesis[J]. Genes Dev,2014,28(5):432-437. doi: 10.1101/gad.233676.113
[18]	Hsu YL, Hung JY, Chou SH, et al. Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression[J]. Oncogene,2015,34(31):4056-4068. doi: 10.1038/onc.2014.333
[19]	Wang L, Shi S, Guo Z, et al. Overexpression of YAP and TAZ is an independent predictor of prognosis in colorectal cancer and related to the proliferation and metastasis of colon cancer cells[J]. PLoS One,2013,8(6):e65539. doi: 10.1371/journal.pone.0065539
[20]	Hong L, Cai Y, Jiang M, et al. The Hippo signaling pathway in liver regeneration and tumorigenesis[J]. Acta Biochim Biophys Sin,2015,47(1):46-52. doi: 10.1093/abbs/gmu106
[21]	Cao JJ, Zhao XM, Wang DL, et al. YAP is overexpressed in clear cell renal cell carcinoma and its knockdown reduces cell proliferation and induces cell cycle arrest and apoptosis[J]. Oncol Rep,2014,32(4):1594-1600. http://cn.bing.com/academic/profile?id=1983691421&encoded=0&v=paper_preview&mkt=zh-cn
[22]	Camargo FD, Gokhale S, Johnnidis JB, et al. YAP1 increases organ size and expands undifferentiated progenitor cells[J]. Curr Biol,2007 ,17(23):2054-2060. doi: 10.1016/j.cub.2007.10.039
[23]	Zhao B, Wei X, Li W, et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control[J]. Genes Dev,2007,21(21):2747-2761. doi: 10.1101/gad.1602907
[24]	Wu H, Xiao Y, Zhang S, et al. The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense[J]. Cell Rep,2013,3(5):1663-1677. doi: 10.1016/j.celrep.2013.04.020
[25]	Lehmann W, Mossmann D, Kleemann J, et al. ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types[J]. Nat Commun,2016,7:10498. doi: 10.1038/ncomms10498
[26]	Li H, Wang S, Wang G, et al. Yes-associated protein expression is a predictive marker for recurrence of hepatocellular carcinoma after liver transplantation[J]. Dig Surg,2014,31(6):468-478. doi: 10.1159/000370252
[27]	Marti P, Stein C, Blumer T, et al. YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors[J]. Hepatology,2015,62(5):1497-1510. doi: 10.1002/hep.27992
[28]	Tao J, Calvisi DF, Ranganathan S, et al. Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice[J]. Gastroenterology,2014,147(3):690-701. doi: 10.1053/j.gastro.2014.05.004
[29]	Lim C, Broqueres-You D, Brouland JP, et al. Hepatic ischemia-reperfusion increases circulating bone marrow-derived progenitor cells and tumor growth in a mouse model of colorectal liver metastases[J]. J Surg Res,2013,184(2):888-897. doi: 10.1016/j.jss.2013.04.069
[30]	Jiao SF, Sun K, Chen XJ, et al. Inhibition of tumor necrosis factor alpha reduces the outgrowth of hepatic micrometastasis of colorectal tumors in a mouse model of liver ischemia-reperfusion injury[J]. J Biomed Sci,2014,21:1. doi: 10.1186/1423-0127-21-1
[31]	Orci LA, Lacotte S, Oldani G, et al. The role of hepatic ischemia-reperfusion injury and liver parenchymal quality on cancer recurrence[J]. Dig Dis Sci,2014,59(9):2058-2068. doi: 10.1007/s10620-014-3182-7
[32]	Yang Y, Del Re DP, Nakano N, et al. miR-206 mediates YAP-induced cardiac hypertrophy and survival[J]. Circ Res,2015,117(10):891-904. doi: 10.1161/CIRCRESAHA.115.306624
[33]	Ma B, Chen Y, Chen L, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase[J]. Nat Cell Biol,2015,17(1):95-103. http://cn.bing.com/academic/profile?id=2091267676&encoded=0&v=paper_preview&mkt=zh-cn
[34]	乔欣,李华,陈规划. Hippo 信号通路与肿瘤、炎症关系的研究进展[J].器官移植,2014,5(6):389-391,398. http://www.organtranspl.com/browse/detail/qkid/91/id/185.html Qiao X, Li H, Chen GH. Advances on the relationship between Hippo signal pathway and tumour, inflammation[J]. Organ Transplant,2014,5(6):389-391,398. http://www.organtranspl.com/browse/detail/qkid/91/id/185.html