留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

肠道微生态与肝移植及肝移植术后缺血性胆道病变的关系

陆建文 董健 张谞丰 吕毅

陆建文, 董健, 张谞丰, 等. 肠道微生态与肝移植及肝移植术后缺血性胆道病变的关系[J]. 器官移植, 2016, 7(4): 315-319. doi: 10.3969/j.issn.1674-7445.2016.04.015
引用本文: 陆建文, 董健, 张谞丰, 等. 肠道微生态与肝移植及肝移植术后缺血性胆道病变的关系[J]. 器官移植, 2016, 7(4): 315-319. doi: 10.3969/j.issn.1674-7445.2016.04.015

肠道微生态与肝移植及肝移植术后缺血性胆道病变的关系

doi: 10.3969/j.issn.1674-7445.2016.04.015
基金项目: 

国家自然科学基金 81470896

详细信息
    通讯作者:

    吕毅,Email:luyi169@126.com

  • 中图分类号: R617

  • 摘要: 近年来随着聚合酶链反应-变性梯度凝胶电泳(PCR-DGGE)及新一代测序技术(包括16S rRNA测序和宏基因组测序技术)的快速发展,肠道微生物作为一个“器官”越来越多地受到关注,相关研究进展突飞猛进。肠道微生物与肝移植术后感染、排斥反应等并发症存在相关性,通过干预肠道微生物可在一定程度上改善上述并发症。缺血性胆管病(IC)是肝移植后并发症的最严重类型,引起IC的原因包括缺血-再灌注损伤、免疫介导损伤及细胞毒性疏水性胆盐等。肠道微生物与上述IC的发病机制之间存在着紧密的联系,由此我们推测肠道微生物可能在肝移植术后IC的发生、发展中发挥重要作用。未来研究可能需着眼于肠道微生物预测IC的敏感性以及通过干预肠道菌群实现有效治疗。

     

  • [1] Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing[J]. Nature,2010,464(7285):59-65. doi: 10.1038/nature08821
    [2] Fukuda S, Toh H, Taylor TD, et al. Acetate-producing bifidobacteria protect the host from enteropathogenic infection via carbohydrate transporters[J]. Gut Microbes,2012,3(5):449-454. doi: 10.4161/gmic.21214
    [3] Chung H, Pamp SJ, Hill JA, et al. Gut immune maturation depends on colonization with a host-specific microbiota[J]. Cell,2012,149(7):1578-1593. doi: 10.1016/j.cell.2012.04.037
    [4] Dorschner P, McElroy LM, Ison MG. Nosocomial infections within the first month of solid organ transplantation[J]. Transpl Infect Dis,2014,16(2):171-187. doi: 10.1111/tid.2014.16.issue-2
    [5] Xie YR, Liu SL, Liu X, et al. Intestinal microbiota and innate immunity-related gene alteration in cirrhotic rats with liver transplantation[J]. Transplant Proc,2011,43(10):3973-3979. doi: 10.1016/j.transproceed.2011.08.113
    [6] Wu ZW, Ling ZX, Lu HF, et al. Changes of gut bacteria and immune parameters in liver transplant recipients[J]. Hepatobiliary Pancreat Dis Int,2012,11(1):40-50. doi: 10.1016/S1499-3872(11)60124-0
    [7] Xie Y, Luo Z, Li Z, et al. Structural shifts of fecal microbial communities in rats with acute rejection after liver transplantation[J]. Microb Ecol,2012,64(2):546-554. doi: 10.1007/s00248-012-0030-1
    [8] Ren Z, Jiang J, Lu H, et al. Intestinal microbial variation may predict early acute rejection after liver transplantation in rats[J]. Transplantation,2014,98(8):844-852. doi: 10.1097/TP.0000000000000334
    [9] Lu H, He J, Wu Z, et al. Assessment of microbiome variation during the perioperative period in liver transplant patients: a retrospective analysis[J]. Microb Ecol,2013,65(3):781-791. doi: 10.1007/s00248-013-0211-6
    [10] Jiang JW, Ren ZG, Cui GY, et al. Chronic bile duct hyperplasia is a chronic graft dysfunction following liver transplantation[J]. World J Gastroenterol,2012,18(10):1038-1047. doi: 10.3748/wjg.v18.i10.1038
    [11] Katchman E, Marquez M, Bazerbachi F, et al. A comparative study of the use of selective digestive decontamination prophylaxis in living-donor liver transplant recipients[J]. Transpl Infect Dis,2014,16(4):539-547. doi: 10.1111/tid.2014.16.issue-4
    [12] Ren ZG, Liu H, Jiang JW, et al. Protective effect of probiotics on intestinal barrier function in malnourished rats after liver transplantation[J]. Hepatobiliary Pancreat Dis Int,2011,10(5):489-496. doi: 10.1016/S1499-3872(11)60083-0
    [13] Xie Y, Chen H, Zhu B, et al. Effect of intestinal microbiota alteration on hepatic damage in rats with acute rejection after liver transplantation[J]. Microb Ecol,2014,68(4):871-880. doi: 10.1007/s00248-014-0452-z
    [14] Dubbeld J, Hoekstra H, Farid W, et al. Similar liver transplantation survival with selected cardiac death donors and brain death donors[J]. Br J Surg,2010,97(5):744-753. doi: 10.1002/bjs.7043
    [15] Gámán G, Gelley F, Doros A, et al. Biliary complications after orthotopic liver transplantation: the Hungarian experience[J]. Transplant Proc,2013,45(10):36953697. http://cn.bing.com/academic/profile?id=2040128380&encoded=0&v=paper_preview&mkt=zh-cn
    [16] Foley DP, Fernandez LA, Leverson G, et al. Biliary complications after liver transplantation from donation after cardiac death donors: an analysis of risk factors and long-term outcomes from a single center[J]. Ann Surg,2011,253(4):817-825. doi: 10.1097/SLA.0b013e3182104784
    [17] op den Dries S, Buis CI, Adelmeijer J, et al. The combination of primary sclerosing cholangitis and CCR5-Δ32 in recipients is strongly associated with the development of nonanastomotic biliary strictures after liver transplantation[J]. Liver Int,2011,31(8):1102-1109. doi: 10.1111/liv.v31.8
    [18] Hohenester S, Wenniger LM, Paulusma CC, et al. A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes[J]. Hepatology,2012,55(1):173-183. doi: 10.1002/hep.24691
    [19] Brunner SM, Junger H, Ruemmele P, et al. Bile duct damage after cold storage of deceased donor livers predicts biliary complications after liver transplantation[J]. J Hepatol,2013,58(6):1133-1139. doi: 10.1016/j.jhep.2012.12.022
    [20] Corbitt N, Kimura S, Isse K, et al. Gut bacteria drive Kupffer cell expansion via MAMP-mediated ICAM-1 induction on sinusoidal endothelium and influence preservation-reperfusion injury after orthotopic liver transplantation[J]. Am J Pathol,2013,182(1):180-191. doi: 10.1016/j.ajpath.2012.09.010
    [21] Ren Z, Cui G, Lu H, et al. Liver ischemic preconditioning (IPC) improves intestinal microbiota following liver transplantation in rats through 16s rDNA-based analysis of microbial structure shift[J]. PLoS One,2013,8(10):e75950. doi: 10.1371/journal.pone.0075950
    [22] Lau K, Benitez P, Ardissone A, et al. Inhibition of type 1 diabetes correlated to a Lactobacillus johnsonii N6.2-mediated Th17 bias[J]. J Immunol,2011,186(6):3538-3546. doi: 10.4049/jimmunol.1001864
    [23] Hand TW, Dos Santos LM, Bouladoux N, et al. Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses[J]. Science,2012,337(6101):1553-1556. doi: 10.1126/science.1220961
    [24] Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species[J]. Science,2011,331(6015):337-341. doi: 10.1126/science.1198469
    [25] Maynard CL, Elson CO, Hatton RD, et al. Reciprocal interactions of the intestinal microbiota and immune system[J]. Nature,2012,489(7415):231-241. doi: 10.1038/nature11551
    [26] Degirolamo C, Rainaldi S, Bovenga F, et al. Microbiota modification with probiotics induces hepatic bile acid synthesis via downregulation of the Fxr-Fgf15 axis in mice[J]. Cell Rep,2014,7(1):12-18. doi: 10.1016/j.celrep.2014.02.032
    [27] Swann JR, Want EJ, Geier FM, et al. Systemic gut microbial modulation of bile acid metabolism in host tissue compartments [J]. Proc Natl Acad Sci U S A,2011,108(Suppl 1):4523-4530. http://cn.bing.com/academic/profile?id=2138546203&encoded=0&v=paper_preview&mkt=zh-cn
    [28] Sayin SI, Wahlstrm A, Felin J, et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist[J]. Cell Metab,2013,17(2):225-235. doi: 10.1016/j.cmet.2013.01.003
    [29] Kakiyama G, Pandak WM, Gillevet PM, et al. Modulation of the fecal bile acid profile by gut microbiota in cirrhosis[J]. J Hepatol,2013,58(5):949-955. doi: 10.1016/j.jhep.2013.01.003
    [30] Kakiyama G, Hylemon PB, Zhou H, et al. Colonic inflammation and secondary bile acids in alcoholic cirrhosi[J]. Am J Physiol Gastrointest Liver Physiol,2014,306(11):G929-G937. doi: 10.1152/ajpgi.00315.2013
    [31] Li F, Jiang C, Krausz KW, et al. Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity[J]. Nat Commun,2013,4:2384. http://cn.bing.com/academic/profile?id=2065147071&encoded=0&v=paper_preview&mkt=zh-cn
    [32] Islam KB, Fukiya S, Hagio M, et al. Bile acid is a host factor that regulates the composition of the cecal microbiota in rats[J]. Gastroenterology,2011,141(5):1773-1781. doi: 10.1053/j.gastro.2011.07.046
    [33] Shankar V, Hamilton MJ, Khoruts A, et al. Species and genus level resolution analysis of gut microbiota in Clostridium difficile patients following fecal microbiota transplantation[J]. Microbiome,2014,2:13. doi: 10.1186/2049-2618-2-13
  • 加载中
计量
  • 文章访问数:  57
  • HTML全文浏览量:  55
  • PDF下载量:  6
  • 被引次数: 0
出版历程
  • 收稿日期:  2016-04-21
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2016-07-15

目录

    /

    返回文章
    返回