调节性B细胞在移植免疫中的研究进展

刘晓武; 邱建新

doi:10.3969/j.issn.1674-7445.2015.05.016

调节性B细胞在移植免疫中的研究进展

doi: 10.3969/j.issn.1674-7445.2015.05.016

刘晓武,
邱建新^,

200080 上海交通大学附属第一人民医院肾移植中心

基金项目:

上海市卫生局新百人计划 XBR2011038

详细信息

通讯作者:
邱建新, Email:jasonqiu@sjtu.edu.cn

中图分类号: R617
计量
- 文章访问数: 88
- HTML全文浏览量: 89
- PDF下载量: 16
- 被引次数: 0
出版历程
- 收稿日期: 2015-05-10
- 网络出版日期: 2021-04-29
- 刊出日期: 2015-09-01

摘要

摘要: 经典移植免疫理论中, B细胞可以作为抗原提呈细胞参与细胞免疫, 亦可通过产生抗体发挥特异性免疫功能。在器官移植中, B细胞的免疫效应也被认为与移植物功能减退及排斥反应有着密切关系。但近期研究发现, 一类新B细胞亚群即调节性B细胞(regulatory B cell, Breg), 在诱导移植免疫耐受及多种自身免疫性疾病发生、发展等起着重要调控作用。Breg的发展及作用机制的研究, 为诱导移植耐受策略提供了新方向。本文主要回顾了已知的Breg的各种表型和相关的免疫调节机制, 并讨论了其在动物移植模型及移植受者中的调控作用。
- 调节性B细胞 /
- 移植免疫 /
- 免疫耐受

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参考文献(30)

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