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老龄供肾在青年受者体内的病理学改变

方佳丽 陈正 马俊杰 李光辉 徐璐 张磊 郭予和 张异蕊 潘光辉

方佳丽, 陈正, 马俊杰, 等. 老龄供肾在青年受者体内的病理学改变[J]. 器官移植, 2015, 6(5): 335-339. doi: 10.3969/j.issn.1674-7445.2015.05.012
引用本文: 方佳丽, 陈正, 马俊杰, 等. 老龄供肾在青年受者体内的病理学改变[J]. 器官移植, 2015, 6(5): 335-339. doi: 10.3969/j.issn.1674-7445.2015.05.012
Fang Jiali, Chen Zheng, Ma Junjie, et al. Pathological changes of renal grafts from elderly donor kidney in young recipients[J]. ORGAN TRANSPLANTATION, 2015, 6(5): 335-339. doi: 10.3969/j.issn.1674-7445.2015.05.012
Citation: Fang Jiali, Chen Zheng, Ma Junjie, et al. Pathological changes of renal grafts from elderly donor kidney in young recipients[J]. ORGAN TRANSPLANTATION, 2015, 6(5): 335-339. doi: 10.3969/j.issn.1674-7445.2015.05.012

老龄供肾在青年受者体内的病理学改变

doi: 10.3969/j.issn.1674-7445.2015.05.012
详细信息
    通讯作者:

    潘光辉, Email:panguanghui@126.com

  • 中图分类号: R617

Pathological changes of renal grafts from elderly donor kidney in young recipients

More Information
  • 摘要:   目的  研究老龄供肾在青年受者体内的病理学改变, 探讨老龄供肾移植的安全性。  方法  研究对象选择2008年1月至2008年12月期间在广州医科大学附属第二医院移植科实施亲属活体供肾移植的14例老龄供者(年龄>55岁)和14例青年受者(年龄 < 30岁)。对每例老龄供肾进行零时活组织检查(活检), 对接受老龄供肾的青年受者在移植后6个月进行常规的移植肾活检。观察老龄供肾移植后的肾脏组织病理结构改变。  结果  老龄供肾移植至青年受者体内6个月后组织病理结构发生改变:肾小动脉病变程度较移植前减轻; 肾小动脉硬化指数较移植前减轻(P < 0.05);肾小球硬化比例移植前后变化不大(P > 0.05)。纤维连接蛋白(FN)水平较移植术前表达水平降低, 但差异无统计学意义(P > 0.05);层黏连蛋白(LN)表达水平较移植前降低(P < 0.05)。  结论  老龄供肾移植到青年受者体内后, 其组织病理学结构有所改善。

     

  • 图  1  老龄供肾移植前与移植后的纤维连接蛋白和层黏连蛋白表达(DAB,×200)

    注:A、B图分别为移植前、移植后的FN表达;C、D图分别为移植前、移植后的LN表达

    Figure  1.  Expression of fibronectin and laminin before and after elderly donor renal transplantation

    表  1  老龄供肾移植前与移植后肾小动脉病变程度变化

    Table  1.   Changes of renal arteriole lesion degree before and after elderly donor renal transplantation (n)

    时间 n 肾小动脉病变程度
    - ± ++
    移植前 14 2 2 5 5
    移植后 14 2 6 6 0
    下载: 导出CSV

    表  2  老龄供肾移植前与移植后FN和LN表达的比较

    Table  2.   Comparison of FN and LN expression before and after elderly donor renal transplantation(x±s)

    时间 n FN LN
    移植前 14 0.180±0.016 0.202±0.011
    移植后 14 0.164±0.026 0.156±0.013
    P 0.087 0.019
    下载: 导出CSV
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出版历程
  • 收稿日期:  2015-06-25
  • 网络出版日期:  2021-04-29
  • 刊出日期:  2015-09-01

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