-
摘要: 器官移植是治疗终末期器官衰竭的有效手段。免疫耐受一直是器官移植领域的研究热点。近年来发现在一些停用免疫抑制剂的受者中发生自发耐受现象, 被称之为临床可操作性耐受。临床可操作性耐受是指在不使用免疫抑制剂的情况下, 至少1年以上无发生移植物排斥反应, 获得移植器官长期存活的现象。本文就临床可操作性耐受的临床证据、预测指标两大方面的研究进展作一综述, 以期为后续研究提供参考。
-
[1] Bishop GA, Ierino FL, Sharland AF, et al. Approaching the promise of operational tolerance in clinical transplantation[J]. Transplantation, 2011, 91(10):1065-1074. doi: 10.1097/TP.0b013e318215e742 [2] Girmanova E, Hruba P, Viklicky O. Circulating biomarkers of tolerance[J]. Transplant Rev, 2015, 29(2):68-72. doi: 10.1016/j.trre.2015.01.003 [3] Sagoo P, Perucha E, Sawitzki B, et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans[J]. J Clin Invest, 2010, 120(6):1848-1861. doi: 10.1172/JCI39922 [4] Newell KA, Asare A, Kirk AD, et al. Identification of a B cell signature associated with renal transplant tolerance in humans[J]. J Clin Invest, 2010, 120(6):1836-1847. doi: 10.1172/JCI39933 [5] Starzl TE, Murase N, Demetris AJ, et al. Lessons of organ-induced tolerance learned from historical clinical experience[J]. Transplantation, 2004, 77(6):926-929. doi: 10.1097/01.TP.0000117780.74133.74 [6] VanBuskirk AM, Burlingham WJ, Jankowska-Gan E, et al. Human allograft acceptance is associated with immune regulation[J]. J Clin Invest, 2000, 106(1):145-155. doi: 10.1172/JCI9171 [7] Moraes-Vieira PM, Silva HM, Takenaka MC, et al. Differential monocyte STAT6 activation and CD4(+)CD25(+)Foxp3(+) T cells in kidney operational tolerance transplanted individuals[J]. Hum Immunol, 2010, 71(5):442-450. doi: 10.1016/j.humimm.2010.01.022 [8] Kawai T, Cosimi AB, Spitzer TR, et al. HLA-mismatched renal transplantation without maintenance immunosuppression[J]. N Engl J Med, 2008, 358(4):353-361. doi: 10.1056/NEJMoa071074 [9] Orlando G, Soker S, Wood K. Operational tolerance after liver transplantation[J]. J Hepatol, 2009, 50(6):1247-1257. doi: 10.1016/j.jhep.2009.03.006 [10] Orlando G, Hematti P, Stratta RJ, et al. Clinical operational tolerance after renal transplantation:current status and future challenges[J]. Ann Surg, 2010, 252(6):915-928. doi: 10.1097/SLA.0b013e3181f3efb0 [11] Feng S, Ekong UD, Lobritto SJ, et al. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants[J]. JAMA, 2012, 307(3):283-293. [12] Waki K, Sugawara Y, Mizuta K, et al. Predicting operational tolerance in pediatric living-donor liver transplantation by absence of HLA antibodies[J]. Transplantation, 2013, 95(1):177-183. doi: 10.1097/TP.0b013e3182782fef [13] Ohe H, Waki K, Yoshitomi M, et al. Factors affecting operational tolerance after pediatric living-donor liver transplantation:impact of early post-transplant events and HLA match[J]. Transpl Int, 2012, 25(1):97-106. doi: 10.1111/tri.2011.25.issue-1 [14] Louis S, Braudeau C, Giral M, et al. Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance[J]. Transplantation, 2006, 81(3):398-407. doi: 10.1097/01.tp.0000203166.44968.86 [15] Waldmann H, Hilbrands R, Howie D, et al. Harnessing FOXP3+ regulatory T cells for transplantation tolerance[J]. J Clin Invest, 2014, 124(4):1439-1445. doi: 10.1172/JCI67226 [16] Pons JA, Revilla-Nuin B, Baroja-Mazo A, et al. FoxP3 in peripheral blood is associated with operational tolerance in liver transplant patients during immunosuppression withdrawal[J]. Transplantation, 2008, 86(10):1370-1378. doi: 10.1097/TP.0b013e318188d3e6 [17] Brouard S, Mansfield E, Braud C, et al. Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance[J]. Proc Natl Acad Sci U S A, 2007, 104(39):15448-15453. doi: 10.1073/pnas.0705834104 [18] Moraes-Vieira PM, Takenaka MC, Silva HM, et al. GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation[J]. Clin Immunol, 2012, 142(2):117-126. doi: 10.1016/j.clim.2011.08.015 [19] Braza F, Soulillou JP, Brouard S. Gene expression signature in transplantation tolerance[J]. Clin Chim Acta, 2012, 413(17/18):1414-1418. [20] Li L, Wozniak LJ, Rodder S, et al. A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation[J]. Am J Transplant, 2012, 12(5):1218-1228. doi: 10.1111/j.1600-6143.2011.03928.x [21] Danger R, Thervet E, Grisoni ML, et al. PARVG gene polymorphism and operational renal allograft tolerance[J]. Transplant Proc, 2012, 44(9):2845-2848. doi: 10.1016/j.transproceed.2012.09.034 [22] Pallier A, Hillion S, Danger R, et al. Patients with drug-free long-term graft function display increased numbers of peripheral B cells with a memory and inhibitory phenotype[J]. Kidney Int, 2010, 78(5):503-513. doi: 10.1038/ki.2010.162 [23] Roden DL, Grey ST. Telling the tiger by its stripes:mapping the genomics of kidney graft tolerance in real time[J]. Kidney Int, 2015, 87(5):875-877. doi: 10.1038/ki.2015.66 [24] Moreso F, Torres IB, Martínez-Gallo M, et al. Gene expression signature of tolerance and lymphocyte subsets in stable renal transplants:results of a cross-sectional study[J]. Transpl Immunol, 2014, 31(1):11-16. doi: 10.1016/j.trim.2014.04.008 [25] Hu M, Wang C, Zhang GY, et al. Infiltrating Foxp3(+) regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance[J]. Am J Transplant, 2013, 13(11):2819-2830. doi: 10.1111/ajt.12445 [26] Hernandez-Fuentes MP, Lechler RI. A'biomarker signature'for tolerance in transplantation[J]. Nat Rev Nephrol, 2010, 6(10):606-613. doi: 10.1038/nrneph.2010.112 [27] 石炳毅.自然杀伤细胞在移植免疫中的双重作用[J].器官移植, 2011, 2(6):301-303. http://www.cnki.com.cn/Article/CJFDTOTAL-QGYZ201106002.htmShi BY. Dual role of natural killer cells in transplantation immunity[J]. Organ Transplant, 2011, 2(6):301-303. http://www.cnki.com.cn/Article/CJFDTOTAL-QGYZ201106002.htm [28] Lozano JJ, Pallier A, Martinez-Llordella M, et al. Comparison of transcriptional and blood cell-phenotypic markers between operationally tolerant liver and kidney recipients[J]. Am J Transplant, 2011, 11(9):1916-1926. doi: 10.1111/j.1600-6143.2011.03638.x [29] Schulz-Juergensen S, Marischen L, Wesch D, et al. Markers of operational immune tolerance after pediatric liver transplantation in patients under immunosuppression[J]. Pediatr Transplant, 2013, 17(4):348-354. doi: 10.1111/petr.2013.17.issue-4 [30] Bohne F, Londoño MC, Benítez C, et al. HCV-induced immune responses influence the development of operational tolerance after liver transplantation in humans[J]. Sci Transl Med, 2014, 6(242):242ra81. [31] Bohne F, Martínez-Llordella M, Lozano JJ, et al. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation[J]. J Clin Invest, 2012, 122(1):368-382. doi: 10.1172/JCI59411
点击查看大图
计量
- 文章访问数: 132
- HTML全文浏览量: 55
- PDF下载量: 14
- 被引次数: 0