体重指数与早期移植肾功能的关系

董丽明; 江艳; 热衣汉·谢力甫; 李莉; 黎明; 米克热衣·艾孜买提

doi:10.3969/j.issn.1674-7445.2015.04.010

体重指数与早期移植肾功能的关系

doi: 10.3969/j.issn.1674-7445.2015.04.010

830000 乌鲁木齐, 新疆医科大学第一附属医院临床营养科(董丽明、江艳、李莉、黎明), 肾病科(热衣汉·谢力甫、米克热衣·艾孜买提)

详细信息

通讯作者:
米克热衣·艾孜买提, Email:dlm0820@163.com

中图分类号: R617
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出版历程
- 收稿日期: 2015-05-06
- 网络出版日期: 2021-01-19
- 刊出日期: 2015-07-15

Correlation between body mass index and early graft function

Department of Clinical Nutrition, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China

More Information

Corresponding author: Mikereyi·Aizimaiti, Email:dlm0820@163.com

摘要

摘要: 目的探讨体重指数(BMI)与早期移植肾功能的关系。方法回顾性研究2003年11月至2014年11月在新疆医科大学第一附属医院肾病科接受同种异体活体肾移植的133例受者的临床资料。根据移植前的BMI将受者分为3组, 消瘦组(BMI < 18.5 kg/m²)、正常体重组(BMI 18.5~23.9 kg/m²)、超重肥胖组(BMI>23.9 kg/m²)。比较3组受者术后1周的实验室指标[血尿素氮(BUN)、血清肌酐(Scr)、血红蛋白、血清白蛋白、总胆固醇和甘油三酯]、移植肾功能延迟恢复发生率, 并对肾移植受者Scr与BMI进行相关分析。结果 3组受者的Scr水平比较差异有统计学意义(P < 0.05);两两比较, 超重肥胖组Scr水平高于正常体重组, 差异有统计学意义(Z=-3.408, P=0.01)。3组肾移植受者血红蛋白、血清白蛋白、总胆固醇水平差异均无统计学意义(均为P>0.05)。肾移植受者Scr水平与BMI呈正相关(r=0.187, P=0.031), Scr水平随BMI增加而升高。结论 BMI影响早期移植肾功能恢复, 肾移植术前控制体重, 有助于改善移植肾功能。
- 肾移植 /
- 体重指数 /
- 受者 /
- 移植肾功能 /
- 肾功能 /
- 血清肌酐
Abstract: Objective To investigate the correlation between body mass index (BMI) and early graft function. Methods Clinical data of 133 recipients underwent renal allograft transplantation in the Department of Nephropathy of the First Affiliated Hospital of Xinjiang Medical University from November 2003 to November 2014 were retrospectively studied. According to BMI before transplantation, the recipients were divided into 3 groups: emaciation group (BMI < 18.5 kg/m²), normal weight group (BMI of 18.5-23.9 kg/m²) and overweight group (BMI>23.9 kg/m²). The laboratory indexes [blood urea nitrogen (BUN), serum creatinine (Scr), hemoglobin, serum albumin, total cholesterol and triglyceride] and the incidence of delayed graft function at 1 week after transplantation were compared among three groups. The correlation between Scr and BMI was analyzed. Results There was significant difference in Scr level among three groups(P < 0.05). In pairwise comparison, Scr level of the overweight group was higher than that of the normal weight group and the difference had statistical significance (Z=-3.408, P=0.01). The hemoglobin, serum albumin and total cholesterol of the three groups showed no difference with statistical significance (all in P>0.05). The Scr level of renal transplant recipients was positively correlated with BMI (r=0.187, P=0.031), and Scr level raised with the increase of BMI. Conclusions BMI influences the recovery of early graft function. To control body weight before transplantation is beneficial to improve graft function.
- Renal transplantation /
- Body mass index /
- Recipient /
- Graft function /
- Renal function /
- Serum creatinine

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表 1 3组肾移植受者血清肌酐、血尿素氮、甘油三酯水平的比较

Table 1. Comparison of serum creatinine, serum urea nitrogen, triglyceride levels among three groups of renal transplant recipients[M(Q)]

组别	n	Scr (μmol/L)	BUN (mmol/L)	甘油三酯 (mmol/L)
消瘦组	15	107(34)	6.4(7.0)	1.45(0.70)
正常体重组	73	100(45)	5.2(4.7)	1.33(0.70)
超重肥胖组	45	118(50)	7.2(2.0)	1.27(0.80)
H值		10.708	1.590	1.450
P值		0.005	0.452	0.833

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表 2 3组肾移植受者血红蛋白、血清白蛋白、总胆固醇水平的比较

Table 2. Comparison of hemoglobin, serum albumin, total cholesterol levels among three groups of renal transplant recipients(x±s)

组别	n	血红蛋白 (g/L)	血清白蛋白 (g/L)	总胆固醇 (mmol/L)
消瘦组	15	102±19	34±5	5.0±1.2
正常体重组	73	104±20	37±5	4.6±1.2
超重肥胖组	45	102±21	36±5	4.6±1.1
F值		0.166	2.221	1.507
P值		0.847	0.113	0.225

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