调节性B细胞与器官移植

宋继勇; 石炳毅

doi:10.3969/j.issn.1674-7445.2015.03.014

调节性B细胞与器官移植

doi: 10.3969/j.issn.1674-7445.2015.03.014

宋继勇,
石炳毅^,

100853 北京, 解放军医学院

基金项目:

国家高技术研究发展计划(863计划)项目 2012AA021002

详细信息

通讯作者:
石炳毅,Email:shibingyi@medmail.com.cn

中图分类号: R617
计量
- 文章访问数: 51
- HTML全文浏览量: 81
- PDF下载量: 20
- 被引次数: 0
出版历程
- 收稿日期: 2015-01-20
- 网络出版日期: 2021-01-19
- 刊出日期: 2015-05-15

摘要

摘要: 调节性免疫细胞网络是目前移植免疫领域研究热点内容之一,其中调节性B细胞(Breg)是新近发现的一群具有负向调节功能的B细胞。目前研究认为,Breg具有表型多样性的特点,主要通过产生白细胞介素(IL)-10、转化生长因子(TGF)-β以及自然抗体等发挥负向调节作用。Breg还有促进调节性T细胞增殖的功能,具有诱导器官移植术后免疫耐受和维持耐受状态的作用。B细胞参与器官移植反应的机制复杂,应将Breg与效应性B细胞区别对待,且如何调控效应性B细胞与有潜在免疫抑制功能的Breg间的平衡至关重要。
- 器官移植 /
- 调节性B细胞 /
- 免疫耐受 /
- 排斥反应

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参考文献(37)

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