钙神经蛋白抑制剂慢性肾毒性模型的建立方法及进展

黄燕纯; 龙文; 黄新坚; 邱江

doi:10.3969/j.issn.1674-7445.2015.02.012

钙神经蛋白抑制剂慢性肾毒性模型的建立方法及进展

doi: 10.3969/j.issn.1674-7445.2015.02.012

510080 广州，中山大学中山医学院(黄燕纯、龙文、黄新坚)；中山大学附属第一医院(邱江)

基金项目:

中山大学临床医学研究"5010"计划项目 2007003

详细信息

通讯作者:
邱江, Email: gnandqj@126.com

中图分类号: R617
计量
- 文章访问数: 131
- HTML全文浏览量: 51
- PDF下载量: 11
- 被引次数: 0
出版历程
- 收稿日期: 2014-11-01
- 刊出日期: 2015-03-01

摘要

摘要: 目前, 钙神经蛋白抑制剂(CNI)肾毒性的机制尚未完全明确, 因此需要建立一个良好的动物模型以供研究, 以更好地研究CNI慢性肾毒性的机制和改善CNI肾毒性的途径。本文将大鼠CNI慢性肾毒性模型的发展过程及目前所采用的几种建立模型的方法(正常饮食CNI肾毒性模型、钠耗竭CNI肾毒性模型、单侧肾切除术CNI肾毒性模型)进行综述。
- 钙神经蛋白抑制剂 /
- 环孢素 /
- 他克莫司 /
- 慢性肾毒性模型

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参考文献(20)

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