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Retinoid X receptor signaling pathway in leukemia

Lu Xiaoxi Ma Zhigui Gao Ju Zhu Yiping

陆晓茜, 马志贵, 高举, 等. 维A酸X受体信号通路与白血病[J]. 器官移植, 2014, 5(6): 383-388. doi: 10.3969/j.issn.1674-7445.2014.06.013
引用本文: 陆晓茜, 马志贵, 高举, 等. 维A酸X受体信号通路与白血病[J]. 器官移植, 2014, 5(6): 383-388. doi: 10.3969/j.issn.1674-7445.2014.06.013
Lu Xiaoxi, Ma Zhigui, Gao Ju, et al. Retinoid X receptor signaling pathway in leukemia[J]. ORGAN TRANSPLANTATION, 2014, 5(6): 383-388. doi: 10.3969/j.issn.1674-7445.2014.06.013
Citation: Lu Xiaoxi, Ma Zhigui, Gao Ju, et al. Retinoid X receptor signaling pathway in leukemia[J]. ORGAN TRANSPLANTATION, 2014, 5(6): 383-388. doi: 10.3969/j.issn.1674-7445.2014.06.013

维A酸X受体信号通路与白血病

doi: 10.3969/j.issn.1674-7445.2014.06.013
基金项目: 

National Natural Science Foundation 81000215

The technology bureau of Chengdu 11DXYB086JH-027

详细信息
    通讯作者:

    朱易萍, Email:yipingzhu918@qq.com

  • 中图分类号: R617

Retinoid X receptor signaling pathway in leukemia

Funds: 

National Natural Science Foundation 81000215

The technology bureau of Chengdu 11DXYB086JH-027

More Information
  • 摘要: 维A酸X受体(RXR)是配体依赖的核转录因子, 在调节一系列生理病理过程中起重要作用。在分子水平上, RXR与多个信号通路相互作用, 调控细胞生长、分化、生存与死亡等靶基因的表达。RXR信号通路网络与其他信号通路之间的相互作用使RXR成为抗肿瘤药物作用的新靶点。本文就RXR信号通路在白血病发生发展中的作用进行简要综述。

     

  • Figure  1.  Simplified diagram of the RXR/RAR signaling network

    Cyclic adenosine monophosphate(cAMP)-protein kinase A (PKA) signal pathway activation induce leukemia cell apoptosis and differentiation. Janus kinase-signal transducer and activator of transcription (JAK-STAT) 3 signal pathway induce leukemia cells apoptosis. Activate MEK pathway show different effect on gene transcription mediated by RXRE

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出版历程
  • 收稿日期:  2014-07-20
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2014-11-15

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