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肾移植术后PRA与移植肾功能长期预后关系的研究

贾保祥 张栋 武俊杰 徐秀红

贾保祥, 张栋, 武俊杰, 等. 肾移植术后PRA与移植肾功能长期预后关系的研究[J]. 器官移植, 2014, 5(6): 360-363. doi: 10.3969/j.issn.1674-7445.2014.06.007
引用本文: 贾保祥, 张栋, 武俊杰, 等. 肾移植术后PRA与移植肾功能长期预后关系的研究[J]. 器官移植, 2014, 5(6): 360-363. doi: 10.3969/j.issn.1674-7445.2014.06.007
Jia Baoxiang, Zhang Dong, Wu Junjie, et al. Study on the relationship between panel reactive antibody and long-term prognosis of transplant renal function[J]. ORGAN TRANSPLANTATION, 2014, 5(6): 360-363. doi: 10.3969/j.issn.1674-7445.2014.06.007
Citation: Jia Baoxiang, Zhang Dong, Wu Junjie, et al. Study on the relationship between panel reactive antibody and long-term prognosis of transplant renal function[J]. ORGAN TRANSPLANTATION, 2014, 5(6): 360-363. doi: 10.3969/j.issn.1674-7445.2014.06.007

肾移植术后PRA与移植肾功能长期预后关系的研究

doi: 10.3969/j.issn.1674-7445.2014.06.007
基金项目: 

国家自然科学基金面上项目 81273271

详细信息
    通讯作者:

    贾保祥, Email:baoxiangjia@sina.com

  • 中图分类号: R617

Study on the relationship between panel reactive antibody and long-term prognosis of transplant renal function

More Information
  • 摘要:   目的  研究肾移植术后患者群体反应性抗体(PRA)对移植肾功能长期预后的影响。  方法   研究对象为首都医科大学附属北京友谊医院1994年1月至2004年12月进行肾移植手术且在术后2周左右行PRA检测并获得随访患者224例。根据肾移植术后2周左右的PRA检测结果分为阴性组(195例)和阳性组(29例)。阴性组患者于2007年再次检测PRA, 两组患者于近期(2013年10月至2014年4月)检测血清肌酐(Scr), 了解肾功能情况。比较PRA阳性患者(含PRA复查阳性者)和PRA阴性患者的移植肾功能长期正常率。  结果   阳性组患者29例, 2014年4月复查18例患者肾功能丧失(17例)或下降(1例), 11例患者肾功能正常。阴性组患者195例, 于2007年复查PRA阴性者153例, 2014年4月复查肾功能正常患者148例, 肾功能下降或丧失者5例;于2007年复查PRA阳性者42例, 移植肾功能均不同程度下降或丧失。2004年前PRA阳性和2007年复查PRA阳性患者共71例, 2014年4月复查肾功能正常患者11例, 移植肾功能长期正常率为15.5%。PRA阴性患者153例, 2014年4月复查肾功能正常患者148例, 移植肾功能长期正常率为96.7%。PRA阳性患者和PRA阴性患者的移植肾长期存活率比较, 差异有统计学意义(P<0.005)。  结论   肾移植术后产生PRA对移植肾长期预后有明显影响。

     

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出版历程
  • 收稿日期:  2014-08-04
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2014-11-15

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