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肾联合造血干细胞移植诱导免疫耐受的研究进展

邱春燕 苗芸

邱春燕, 苗芸. 肾联合造血干细胞移植诱导免疫耐受的研究进展[J]. 器官移植, 2014, 5(6): 338-342. doi: 10.3969/j.issn.1674-7445.2014.06.002
引用本文: 邱春燕, 苗芸. 肾联合造血干细胞移植诱导免疫耐受的研究进展[J]. 器官移植, 2014, 5(6): 338-342. doi: 10.3969/j.issn.1674-7445.2014.06.002

肾联合造血干细胞移植诱导免疫耐受的研究进展

doi: 10.3969/j.issn.1674-7445.2014.06.002
基金项目: 

南方医科大学南方医院院长基金 2013B011

详细信息
    作者简介:

    苗芸, Email:miaoyunecho@126.com

  • 中图分类号: R617

  • 图  1  混合嵌合体诱导中枢克隆清除性免疫耐受的可能机制

    注:A图为阳性选择,双阳性细胞识别受体胸腺上皮细胞表面MHC分子→与之结合→T淋巴细胞存活并分化为CD4或CD8单阳性细胞,否则发生凋亡;B图为阴性选择,单阳性细胞识别供体APC表面供体抗原肽-MHC分子复合物→与之结合→发生凋亡或失能,否则可存活并继续分化、发育成为成熟T细胞(引自:龚非力. 医学免疫学[M]. 北京: 科学出版社, 2007:72.)

    Figure  1.  Possible mechanism of mixed chimerism inducing central immunotolerance through clonal deletion

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出版历程
  • 收稿日期:  2014-07-15
  • 网络出版日期:  2021-01-19
  • 刊出日期:  2014-11-15

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