留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

调节性T细胞体外诱导及其在器官移植中应用的研究进展

覃伟 杨扬

覃伟, 杨扬. 调节性T细胞体外诱导及其在器官移植中应用的研究进展[J]. 器官移植, 2014, 5(5): 324-327. doi: 10.3969/j.issn.1674-7445.2014.05.014
引用本文: 覃伟, 杨扬. 调节性T细胞体外诱导及其在器官移植中应用的研究进展[J]. 器官移植, 2014, 5(5): 324-327. doi: 10.3969/j.issn.1674-7445.2014.05.014

调节性T细胞体外诱导及其在器官移植中应用的研究进展

doi: 10.3969/j.issn.1674-7445.2014.05.014
基金项目: 

国家自然科学基金 81370575

教育部博士点基金 20120171110082

第二军医大学东方肝胆外科医院国家科技重大专项合作 2012ZX10002010-001-007

详细信息
    通讯作者:

    杨扬,Email:yysysu@163.com

  • 中图分类号: R617

  • 摘要: 器官移植是目前国内外公认的治疗终末期疾病、挽救生命和提高生存质量的有效措施。移植后免疫排斥反应仍是器官移植的主要术后并发症,影响受者长期存活。虽然免疫抑制剂在临床应用中显示了良好的效果,但这些药物长期应用会使受者处于免疫低下状态,进而发生感染、肿瘤及其他并发症。

     

  • [1] Sakaguchi S, Sakaguchi N, Asano M, et al. Pillars article: immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995[J].J Immunol,2011,186(7):3808-3821. http://cn.bing.com/academic/profile?id=2470754739&encoded=0&v=paper_preview&mkt=zh-cn
    [2] Ramsdell F. Foxp3 and natural regulatory T cells: key to a cell lineage?[J]. Immunity,2003,19(2):165-168. doi: 10.1016/S1074-7613(03)00207-3
    [3] 马东霞,王璐,赵越, 等. OX40信号调节抑制小鼠CD4+ CD25+调节性T淋巴细胞Foxp3的表达[J].中华器官移植杂志,2013,34(7):424-427.

    Ma DX, Wang L, Zhao Y, et al. OX40 stimulation down-regulates the expression of Foxp3 in CD4+ CD25+ regulatory T cells[J]. Chin J Organ Transplant,2013,34(7):424-427.
    [4] Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function[J]. Nature,2007,450(7169):566-569. doi: 10.1038/nature06306
    [5] Shevach EM. Mechanisms of foxp3+ T regulatory cell-mediated suppression[J]. Immunity,2009,30(5):636-645. doi: 10.1016/j.immuni.2009.04.010
    [6] Tadokoro CE, Shakhar G, Shen S, et al. Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo[J]. J Exp Med,2006,203(3):505-511. doi: 10.1084/jem.20050783
    [7] Chou HS, Hsieh CC, Charles R, et al. Myeloid-derived suppressor cells protect islet transplants by B7-H1 mediated enhancement of T regulatory cells[J]. Transplantation,2012,93(3):272-282. doi: 10.1097/TP.0b013e31823ffd39
    [8] Chattopadhyay G, Shevach EM. Antigen-specific induced T regulatory cells impair dendritic cell function via an IL-10/MARCH1-dependent mechanism[J]. J Immunol,2013,191(12):5875-5884. doi: 10.4049/jimmunol.1301693
    [9] Earle KE, Tang Q, Zhou X, et al. In vitro expanded human CD4+ CD25+ regulatory T cells suppress effector T cell proliferation[J]. Clin Immunol,2005,115(1):3-9.
    [10] 王永磊,朱志军. CD4+ CD25+调节性T细胞体内外培养扩增方法的研究进展[J].器官移植,2012,3(5):278-282. http://www.organtranspl.com/browse/detail/qkid/37/id/624.html

    Wang YL, Zhu ZJ. Progress of study on expansion of CD4+ CD25+T regulatory cells in vitro and in vivo culture[J]. Organ Transplant,2012,3(5):278-282. http://www.organtranspl.com/browse/detail/qkid/37/id/624.html
    [11] Hoffmann P, Eder R, Kunz-Schughart LA, et al. Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells[J]. Blood,2004,104(3):895-903. doi: 10.1182/blood-2004-01-0086
    [12] Wang J, Huizinga TW, Toes RE. De novo generation and enhanced suppression of human CD4+ CD25+ regulatory T cells by retinoic acid[J]. J Immunol,2009,183(6):4119-4126. doi: 10.4049/jimmunol.0901065
    [13] Zhang W, Zhang D, Shen M, et al. Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance[J]. J Immunol,2010,185(8):4750-4759. doi: 10.4049/jimmunol.1000769
    [14] Hippen KL, Merkel SC, Schirm DK, et al. Massive ex vivo expansion of human natural regulatory T cells (Tregs) with minimal loss of in vivo functional activity[J]. Sci Transl Med,2011,3(83):83ra41. http://cn.bing.com/academic/profile?id=2145353379&encoded=0&v=paper_preview&mkt=zh-cn
    [15] Lu L, Ma J, Li Z, et al. All-trans retinoic acid promotes TGF-β-induced Tregs via histone modification but not DNA demethylation on Foxp3 gene locus[J]. PLoS One,2011,6(9):e24590. doi: 10.1371/journal.pone.0024590
    [16] Joffre O, Santolaria T, Calise D, et al. Prevention of acute and chronic allograft rejection with CD4+ CD25+ Foxp3+ regulatory T lymphocytes[J]. Nat Med,2008,14(1):88-92. doi: 10.1038/nm1688
    [17] Feng G, Nadig SN, Bäckdahl L, et al. Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection[J]. Sci Transl Med,2011,3(83):83ra40. http://cn.bing.com/academic/profile?id=2157643208&encoded=0&v=paper_preview&mkt=zh-cn
    [18] Sagoo P, Ali N, Garg G, et al. Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells[J]. Sci Transl Med,2011,3(83):83ra42. http://cn.bing.com/academic/profile?id=2018715802&encoded=0&v=paper_preview&mkt=zh-cn
    [19] Wright GP, Notley CA, Xue SA, et al. Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis[J]. Proc Natl Acad Sci U S A,2009,106(45):19078-19083. doi: 10.1073/pnas.0907396106
    [20] Tsang JY, Tanriver Y, Jiang S, et al. Conferring indirect allospecificity on CD4+ CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice[J]. J Clin Invest,2008,118(11):3619-3628. doi: 10.1172/JCI33185
    [21] Peters JH, Hilbrands LB, Koenen HJ, et al. Ex vivo generation of human alloantigen-specific regulatory T cells from CD4(pos)CD25(high) T cells for immunotherapy[J]. PLoS One,2008,3(5):e2233. doi: 10.1371/journal.pone.0002233
    [22] Wang X, Lu L, Jiang S. Regulatory T cells: customizing for the clinic[J]. Sci Transl Med,2011,3(83):83ps19. http://cn.bing.com/academic/profile?id=2096286372&encoded=0&v=paper_preview&mkt=zh-cn
    [23] Cohen JL, Trenado A, Vasey D, et al. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease[J]. J Exp Med,2002,196(3):401-406. doi: 10.1084/jem.20020090
    [24] Hanash AM, Levy RB. Donor CD4+ CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation[J]. Blood,2005,105(4):1828-1836. doi: 10.1182/blood-2004-08-3213
    [25] Trzonkowski P, Bieniaszewska M, Juścińska J, et al. First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+ CD25+ CD127- T regulatory cells[J]. Clin Immunol,2009,133(1):22-26. doi: 10.1016/j.clim.2009.06.001
    [26] Edinger M, Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences[J]. Curr Opin Immunol,2011,23(5):679-684. doi: 10.1016/j.coi.2011.06.006
    [27] Di Ianni M, Falzetti F, Carotti A, et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation[J].Blood,2011,117(14):3921-3928. doi: 10.1182/blood-2010-10-311894
    [28] Lu L, Blazar B, Li MY. Safety Study of Using Regulatory T Cells Induce Liver Transplantation Tolerance(Treg)[EB/OL]. (2013-08-01). http://clinicaltrials.gov/show/NCT01624077.
    [29] [European Commission. ONE Study[EB/OL]. (2013-08-04).www.onestudy.org.
    [30] Berglund D, Karlsson M, Biglarnia AR, et al. Obtaining regulatory T cells from uraemic patients awaiting kidney transplantation for use in clinical trials[J]. Clin Exp Immunol,2013,173(2):310-322. doi: 10.1111/cei.2013.173.issue-2
    [31] Sato Y, Chikako T, Oya H, et al. Regulatory T-cell activation among patients who displayed operational tolerance following intra-portal administration of donor-specific antigens in living donor liver transplantation[J]. Transplant Proc,2012,44(2):560-564. doi: 10.1016/j.transproceed.2012.01.045
    [32] Nguyen MT, Fryml E, Sahakian SK, et al. Pretransplantation recipient regulatory T cell suppressive function predicts delayed and slow graft function after kidney transplantation[J]. Transplantation,2014,DOI: 10.1097/TP.0000000000000219[Epub ahead of print].
    [33] Selin LK, Brehm MA, Naumov YN,et al. Memory of mice and men: CD8+ T-cell cross-reactivity and heterologous immunity[J]. Immunol Rev,2006,211: 164-181. doi: 10.1111/imr.2006.211.issue-1
  • 加载中
计量
  • 文章访问数:  65
  • HTML全文浏览量:  9
  • PDF下载量:  4
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-05-16
  • 刊出日期:  2014-09-15

目录

    /

    返回文章
    返回