留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

T淋巴细胞在缺血-再灌注损伤中的重要作用

饶建华 王学浩

饶建华, 王学浩. T淋巴细胞在缺血-再灌注损伤中的重要作用[J]. 器官移植, 2014, 5(5): 261-265. doi: 10.3969/j.issn.1674-7445.2014.05.001
引用本文: 饶建华, 王学浩. T淋巴细胞在缺血-再灌注损伤中的重要作用[J]. 器官移植, 2014, 5(5): 261-265. doi: 10.3969/j.issn.1674-7445.2014.05.001

T淋巴细胞在缺血-再灌注损伤中的重要作用

doi: 10.3969/j.issn.1674-7445.2014.05.001
基金项目: 

国家科学自然基金 81270553、81100270、81070380

江苏省"科教兴卫"工程医学重点学科课题 Z2006005

详细信息
    通讯作者:

    王学浩,中国工程院院士,教授,主任医师,博士研究生导师,国际著名肝胆外科、肝移植专家。现任南京医科大学第一附属医院肝脏外科研究所所长、江苏省肝移植中心主任、国家卫生和计划生育委员会(卫计委)器官移植临床重点专科主任、卫计委活体肝移植重点实验室主任。兼任国际肝胆胰协会理事、国际器官移植协会理事、中华医学会移植免疫学组组长等10余个专业学会的副主任委员或委员。兼任《器官移植》、《中华器官移植杂志》、《中华肝胆外科杂志》等20余家专业杂志副主编、常务编委或编委。中国大陆活体肝移植领域的开拓者,开展了国内首例活体肝移植、国内首例不含肝中静脉成人右叶供肝活体肝移植、国内首例成人扩大右叶(含肝中静脉)供肝活体肝移植。在亲体肝移植治疗肝豆状核变性的基础和临床研究方面提出创新性见解。中国肝癌介入治疗的开创者,倡导肝癌以手术为主的现代综合治疗。完成或承担国家自然基金课题、八五国家科技攻关课题5项,省部级科研课题20余项。主编或参编学术专著10余部,发表学术论文400余篇,其中科学引文索引(Science Citation Index,SCI)论文66篇。作为第一完成人获国家科技进步二等奖1项,省部级二等奖以上奖项8项。荣获"全国卫生系统先进工作者"、"南京市十大科技之星"、"南京市劳动模范"、"南京市科技功臣"、"江苏省白求恩式卫生工作者"、"江苏省先进工作者"等称号。

  • 中图分类号: R617;R392

  • 摘要: 缺血-再灌注损伤(IRI)可在多种临床环境(器官移植、分段切除)中发生,可以导致缺血器官功能障碍和衰竭。虽然先天性免疫反应在IRI中发挥重要作用,但是T淋巴细胞也参与IRI的发病过程,包括CD4+T淋巴细胞、CD8+T淋巴细胞、γT淋巴细胞等。

     

  • [1] Brait VH, Arumugam TV, Drummond GR, et al. Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia[J]. J Cereb Blood Flow Metab,2012,32(4):598-611. doi: 10.1038/jcbfm.2012.6
    [2] Yilmaz G, Arumugam TV, Stokes KY, et al. Role of T lymphocytes and interferon-gamma in ischemic stroke[J]. Circulation,2006,113(17):2105-2112. doi: 10.1161/CIRCULATIONAHA.105.593046
    [3] Shichita T, Sugiyama Y, Ooboshi H, et al. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury[J]. Nat Med,2009,15(8):946-950. doi: 10.1038/nm.1999
    [4] Hochegger K, Schätz T, Eller P, et al. Role of alpha/beta and gamma/delta T cells in renal ischemia-reperfusion injury[J].Am J Physiol Renal Physiol,2007,293(3):F741-F747. doi: 10.1152/ajprenal.00486.2006
    [5] Kuboki S, Sakai N, Tsch p J, et al. Distinct contributions of CD4+ T cell subsets in hepatic ischemia/reperfusion injury[J]. Am J Physiol Gastrointest Liver Physiol,2009,296(5):G1054-G1059. doi: 10.1152/ajpgi.90464.2008
    [6] Satpute SR, Park JM, Jang HR, et al. The role for T cell repertoire/antigen-specific interactions in experimental kidney ischemia reperfusion injury[J]. J Immunol,2009,183(2):984-992. doi: 10.4049/jimmunol.0801928
    [7] Li L, Huang L, Vergis AL, et al. IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury[J]. J Clin Invest,2010,120(1):331-342. doi: 10.1172/JCI38702
    [8] Zhai Y, Qiao B, Gao F, et al. Type Ⅰ, but not type Ⅱ, interferon is critical in liver injury induced after ischemia and reperfusion[J]. Hepatology,2008,47(1):199-206. http://cn.bing.com/academic/profile?id=2055656686&encoded=0&v=paper_preview&mkt=zh-cn
    [9] Shen XD, Ke B, Ji H, et al. Disruption of Type-Ⅰ IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism[J]. Am J Transplant,2012,12(7):1730-1739. doi: 10.1111/j.1600-6143.2012.04021.x
    [10] Andrade RM, Wessendarp M, Subauste CS. CD154 activates macrophage antimicrobial activity in the absence of IFN-gamma through a TNF-alpha-dependent mechanism[J]. J Immunol,2003,171(12):6750-6756. doi: 10.4049/jimmunol.171.12.6750
    [11] Abdi K, Singh NJ. Antigen-activated T cells induce IL-12p75 production from dendritic cells in an IFN-γ-independent manner[J]. Scand J Immunol,2010,72(6):511-521. doi: 10.1111/sji.2010.72.issue-6
    [12] Ji H, Shen X, Gao F, et al. Programmed death-1/B7-H1 negative costimulation protects mouse liver against ischemia and reperfusion injury[J]. Hepatology, 2010,52(4):1380-1389. doi: 10.1002/hep.23843
    [13] Uchida Y, Ke B, Freitas MC, et al. The emerging role of T cell immunoglobulin mucin-1 in the mechanism of liver ischemia and reperfusion injury in the mouse[J]. Hepatology,2010,51(4):1363-1372. doi: 10.1002/hep.23442
    [14] Zhang Y, Ji H, Shen X, et al. Targeting TIM-1 on CD4 T cells depresses macrophage activation and overcomes ischemia-reperfusion injury in mouse orthotopic liver transplantation[J]. Am J Transplant,2013,13(1):56-66. doi: 10.1111/j.1600-6143.2012.04316.x
    [15] Kono H, Fujii H, Ogiku M, et al. Role of IL-17A in neutrophil recruitment and hepatic injury after warm ischemia-reperfusion mice[J]. J Immunol,2011,187(9):4818-4825. doi: 10.4049/jimmunol.1100490
    [16] Feng M, Li G, Qian X, et al. IL-17A-producing NK cells were implicated in liver injury induced by ischemia and reperfusion[J]. Int Immunopharmacol, 2012, 13(2):135-140. doi: 10.1016/j.intimp.2012.03.007
    [17] Tan Z, Jiang R, Wang X, et al. RORγt+IL-17+ neutrophils play a critical role in hepatic ischemia-reperfusion injury[J]. J Mol Cell Biol,2013,5(2):143-146. doi: 10.1093/jmcb/mjs065
    [18] Loi P, Yuan Q, Torres D, et al. Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury[J]. Hepatology,2013,57(1):351-361. doi: 10.1002/hep.26022
    [19] Eggenhofer E, Rovira J, Sabet-Baktach M, et al. Unconventional RORγt+ T cells drive hepatic ischemia reperfusion injury[J]. J Immunol,2013,191(1):480-487. doi: 10.4049/jimmunol.1202975
    [20] Park SW, Kim M, Brown KM, et al. Paneth cell-derived interleukin-17A causes multiorgan dysfunction after hepatic ischemia and reperfusion injury[J]. Hepatology,2011,53(5):1662-1675. doi: 10.1002/hep.24253
    [21] Gelderblom M, Weymar A, Bernreuther C, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke[J]. Blood, 2012,120(18):3793-3802. doi: 10.1182/blood-2012-02-412726
    [22] Ranganathan PV, Jayakumar C, Mohamed R, et al. Netrin-1 regulates the inflammatory response of neutrophils and macrophages, and suppresses ischemic acute kidney injury by inhibiting COX-2-mediated PGE2 production[J]. Kidney Int,2013,83(6):1087-1098. doi: 10.1038/ki.2012.423
    [23] Liao YH, Xia N, Zhou SF, et al. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration[J]. J Am Coll Cardiol,2012,59(4):420-429. doi: 10.1016/j.jacc.2011.10.863
    [24] Sharma AK, LaPar DJ, Zhao Y, et al. Natural killer T cell-derived IL-17 mediates lung ischemia-reperfusion injury[J]. Am J Respir Crit Care Med, 2011, 183(11):1539-1549. doi: 10.1164/rccm.201007-1173OC
    [25] Hata T, Takahashi M, Hida S, et al. Critical role of Th17 cells in inflammation and neovascularization after ischaemia[J]. Cardiovasc Res,2011,90(2):364-372. doi: 10.1093/cvr/cvq397
    [26] Gandolfo MT, Jang HR, Bagnasco SM, et al. Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury[J]. Kidney Int,2009,76(7):717-729. doi: 10.1038/ki.2009.259
    [27] Kleinschnitz C, Kraft P, Dreykluft A, et al. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature[J]. Blood,2013,121(4):679-691. doi: 10.1182/blood-2012-04-426734
    [28] Zouggari Y, Ait-Oufella H, Waeckel L, et al. Regulatory T cells modulate postischemic neovascularization[J]. Circulation,2009,120(14):1415-1425. doi: 10.1161/CIRCULATIONAHA.109.875583
    [29] Kinsey GR, Huang L, Jaworska K, et al. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection[J]. J Am Soc Nephrol, 2012, 23(9):1528-1537. doi: 10.1681/ASN.2012010070
    [30] Kim MG, Jung Cho E, Won Lee J, et al. The heat-shock protein-70-induced renoprotective effect is partially mediated by CD4+ CD25+ Foxp3+ regulatory T cells in ischemia/reperfusion-induced acute kidney injury[J]. Kidney Int, 2014,85(1):62-71. doi: 10.1038/ki.2013.277
    [31] Feng M, Wang Q, Zhang F, et al. Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury[J]. Int Immunopharmacol,2012,12(1):189-196. doi: 10.1016/j.intimp.2011.11.010
  • 加载中
计量
  • 文章访问数:  107
  • HTML全文浏览量:  59
  • PDF下载量:  8
  • 被引次数: 0
出版历程
  • 收稿日期:  2014-05-10
  • 刊出日期:  2014-09-15

目录

    /

    返回文章
    返回