肝移植术后糖尿病的可逆性预测因子分析

徐晓东; 谢汝莹; 林硕; 舒冏; 王曼曼; 穆攀伟; 杨扬; 陈规划; 曾龙驿

doi:10.3969/j.issn.1674-7445.2014.01.007

肝移植术后糖尿病的可逆性预测因子分析

doi: 10.3969/j.issn.1674-7445.2014.01.007

1.
321000 浙江大学金华医院内分泌科(徐晓东)
2.
中山大学附属第三医院内分泌科(徐晓东、谢汝莹、林硕、舒冏、王曼曼、穆攀伟、曾龙驿, 徐晓东原为该单位硕士研究生)，肝移植中心(杨扬、陈规划)

基金项目:

广东省科技计划项目 2006B36003024

详细信息

通讯作者:
曾龙驿,Email:175625392@qq.com

中图分类号: R617
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- 被引次数: 0
出版历程
- 收稿日期: 2013-11-06
- 网络出版日期: 2021-01-19
- 刊出日期: 2014-01-15

Analysis of predictive factors associated with the reversibility of post-transplantation diabetes mellitus

1.
Department of Endocrinology, Jinhua Hospital of Zhejiang University, Jinhua 321000, China

摘要

摘要: 目的探讨肝移植术后糖尿病(post-transplantation diabetes mellitus, PTDM)的可逆性预测因子。 方法 回顾性分析中山大学附属第三医院肝移植中心2004年4月至2009年6月实施肝移植的618例患者的临床资料,最终纳入研究190例。根据其高血糖状态是否为持续性分为可逆性PTDM组和不可逆性PTDM组。对可能影响两组患者糖代谢情况的术前资料(年龄、性别、体重指数、术前空腹血糖、肝硬化病史、高血压病史)和术后资料(排斥反应、激素用量、钙神经蛋白抑制剂的选择)进行单因素统计学分析。结果 102例患者的PTDM是可逆的,占69.9%,与不可逆组相比,可逆组患者年龄较轻[(43±11)比(52±10)岁,P<0.05],其余相关因素差异无统计学意义(P>0.05)。结论患者接受器官移植时的年龄是PTDM可逆性的预测因子。
- 肝移植术后糖尿病 /
- 可逆性 /
- 预测因子 /
- 年龄
Abstract: Objective To investigate the predictive factors associated with the reversibility of post-transplantation diabetes mellitus(PTDM). Method Clinical data of 618 patients who underwent liver transplantation from April 2004 to June 2009 in the Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University were retrospectively analyzed, in which 190 patients were included in the study. According to the persistence of hyperglycemia, patients were divided into two groups: reversible PTDM group and irreversible PTDM group. Preoperative data (age, gender, body mass index, pre-transplantation fasting plasma glucose, liver cirrhosis history, hypertension history) and postoperative data (rejection, dose of glucocorticoid, choice of calcineurin inhibitor) which might affect the glycometabolism of patients between two groups were analyzed by univariate factor analysis. Result PTDM in 102 patients (69.9%) was reversible. Compared with irreversible PTDM group, age of patients was younger in reversible PTDM group[(43±11)years old vs. (52±10)years old, P<0.05]. And there was no significant difference in the other factors(all in P>0.05). Conclusion Age of patients received organ transplantation is the predictive factor associated with the reversibility of PTDM.
- Post-transplantation diabetes mellitus /
- Reversibility /
- Predictive factor /
- Age

HTML全文

表 1 两组PTDM患者的临床资料比较(计数资料)

Table 1. Comparison of clinical data of PTDM patients between two groups(count data)

项目	可逆组(n=102)	不可逆组(n=44)	χ²值	P值
性别(男性)	90	42	1.848	0.174
术前肝硬化病史	75	30	0.324	0.569
术前高血压病史	8	6	1.190	0.275
术后排斥反应	8	5	0.470	0.493
应用大剂量激素	52	27	1.335	0.248
应用CNI(含FK506)	92	43	2.503	0.114

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表 2 两组PTDM患者的临床资料比较(计量资料)

Table 2. Comparison of clinical data of PTDM patients between two groups(measurement data)

项目	可逆组(n=102)	不可逆组(n=44)	t值	P值
平均年龄(岁)	43±11	52±10	-0.875	＜0.05
体重指数(kg/m²)	23±3	24±4	-1.616	0.228
术后空腹血糖(mmol/L)	4.5±1.2	5.3±1.3	-3.609	0.271

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参考文献(15)

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