Volume 13 Issue 3
May  2022
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Luo Zihuan, Sun Qiquan. Research highlights on kidney transplantation in 2021: voices from China[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 325-332. doi: 10.3969/j.issn.1674-7445.2022.03.007
Citation: Luo Zihuan, Sun Qiquan. Research highlights on kidney transplantation in 2021: voices from China[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 325-332. doi: 10.3969/j.issn.1674-7445.2022.03.007
shu

Research highlights on kidney transplantation in 2021: voices from China

doi: 10.3969/j.issn.1674-7445.2022.03.007

  • Department of Kidney Transplantation, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China

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  • Corresponding author: Sun Qiquan, Email: sunqiq@mail.sysu.edu.cn
  • Received Date: 2022-02-25
  • Publish Date: 2022-05-15
    Abstract
  • Over the past 70 years, kidney transplantation has become not only the most mature but also the highest-success-rate surgery among all organ transplantation surgeries. However, the long-term survival of kidney transplant recipients is still challenged by such key factors as ischemia-reperfusion injury related to kidney transplantation, rejection, chronic renal allograft dysfunction, renal allograft fibrosis, immunosuppressive therapy, infections and others. Relevant fundamental and clinical studies have emerged endlessly. At the same time, the research related to kidney transplantation also becomes a new hot spot accordingly in the context of the normalization of novel coronavirus pneumonia. This article reviewed the cutting-edge hot spots in relation to the fundamental and clinical aspects of kidney transplantation together with relevant new techniques and new visions. The studies included in this article focused on the reports published by Chinese teams that are more applicable to the current situation of kidney transplantation in China, for the purpose of providing new thoughts and strategies for the diagnosis and treatment of kidney transplantation related issues in China.

     

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  • [1]
    FENIG Y, SURESH S, ROCHON C. Long-term survival after kidney transplantation[J]. N Engl J Med, 2022, 386(5): 499. DOI: 10.1056/NEJMc2115207.
    [2]
    REESE PP, BOUDVILLE N, GARG AX. Living kidney donation: outcomes, ethics, and uncertainty[J]. Lancet, 2015, 385(9981): 2003-2013. DOI: 10.1016/S0140-6736(14)62484-3.
    [3]
    KAMINSKI H, MARSERES G, YARED N, et al. mTOR inhibitors prevent CMV infection through the restoration of functional αβ and γδ T cells in kidney transplantation[J]. J Am Soc Nephrol, 2022, 33(1): 121-137. DOI: 10.1681/ASN.2020121753.
    [4]
    OELLERICH M, SHERWOOD K, KEOWN P, et al. Liquid biopsies: donor-derived cell-free DNA for the detection of kidney allograft injury[J]. Nat Rev Nephrol, 2021, 17(9): 591-603. DOI: 10.1038/s41581-021-00428-0.
    [5]
    PONTICELLI C, CAMPISE MR. The inflammatory state is a risk factor for cardiovascular disease and graft fibrosis in kidney transplantation[J]. Kidney Int, 2021, 100(3): 536-545. DOI: 10.1016/j.kint.2021.04.016.
    [6]
    RUGGENENTI P, CRAVEDI P, GOTTI E, et al. Mycophenolate mofetil versus azathioprine in kidney transplant recipients on steroid-free, low-dose cyclosporine immunosuppression (ATHENA): a pragmatic randomized trial[J]. PLoS Med, 2021, 18(6): e1003668. DOI: 10.1371/journal.pmed.1003668.
    [7]
    ASANO Y, DACCACHE J, JAIN D, et al. Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection[J]. Nat Commun, 2021, 12(1): 4372. DOI: 10.1038/s41467-021-24615-6.
    [8]
    ISHIYAMA K, ARAKAWA-HOYT J, AGUILAR OA, et al. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients[J]. Proc Natl Acad Sci U S A, 2022, 119(8): e2116588119. DOI: 10.1073/pnas.2116588119.
    [9]
    SHEN Q, WANG Y, CHEN J, et al. Single-cell RNA sequencing reveals the immunological profiles of renal allograft rejection in mice[J]. Front Immunol, 2021, 12: 693608. DOI: 10.3389/fimmu.2021.693608.
    [10]
    LIN Y, WANG L, GE W, et al. Multi-omics network characterization reveals novel microRNA biomarkers and mechanisms for diagnosis and subtyping of kidney transplant rejection[J]. J Transl Med, 2021, 19(1): 346. DOI: 10.1186/s12967-021-03025-8.
    [11]
    BENOTMANE I, SOLIS M, VELAY A, et al. Intravenous immunoglobulin as a preventive strategy against BK virus viremia and BKV-associated nephropathy in kidney transplant recipients-results from a proof-of-concept study[J]. Am J Transplant, 2021, 21(1): 329-337. DOI: 10.1111/ajt.16233.
    [12]
    KOYRO TF, KRAUS E, LUNEMANN S, et al. Upregulation of HLA-F expression by BK polyomavirus infection induces immune recognition by KIR3DS1-positive natural killer cells[J]. Kidney Int, 2021, 99(5): 1140-1148. DOI: 10.1016/j.kint.2020.12.014.
    [13]
    XU L, QU H, ALONSO DG, et al. Portable integrated digital PCR system for the point-of-care quantification of BK virus from urine samples[J]. Biosens Bioelectron, 2021, 175: 112908. DOI: 10.1016/j.bios.2020.112908.
    [14]
    GERHARDT LMS, LIU J, KOPPITCH K, et al. Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury[J]. Proc Natl Acad Sci U S A, 2021, 118(27): e2026684118. DOI: 10.1073/pnas.2026684118.
    [15]
    YAN R, REN J, WEN J, et al. Enzyme therapeutic for ischemia and reperfusion injury in organ transplantation[J]. Adv Mater, 2022, 34(1): e2105670. DOI: 10.1002/adma.202105670.
    [16]
    ZHANG D, WANG Y, ZENG S, et al. Integrated analysis of prognostic genes associated with ischemia-reperfusion injury in renal transplantation. [J] Front Immunol, 2021, 12: 747020. DOI: 10.3389/fimmu.2021.747020.
    [17]
    KE J, ZHAO F, LUO Y, et al. MiR-124 negatively regulated PARP1 to alleviate renal ischemia-reperfusion injury by inhibiting TNFα/RIP1/RIP3 pathway[J]. Int J Biol Sci, 2021, 17(8): 2099-2111. DOI: 10.7150/ijbs.58163.
    [18]
    ZHENG H, ZHANG Y, LI L, et al. Depletion of Toll-like receptor-9 attenuates renal tubulointerstitial fibrosis after ischemia-reperfusion injury[J]. Front Cell Dev Biol, 2021, 9: 641527. DOI: 10.3389/fcell.2021.641527.
    [19]
    ZHENG H, ZHANG Y, HE J, et al. Hydroxychloroquine inhibits macrophage activation and attenuates renal fibrosis after ischemia-reperfusion injury[J]. Front Immunol, 2021, 12: 645100. DOI: 10.3389/fimmu.2021.645100.
    [20]
    LI Y, XU B, YANG J, et al. Liraglutide protects against lethal renal ischemia-reperfusion injury by inhibiting high-mobility group box 1 nuclear-cytoplasmic translocation and release[J]. Pharmacol Res, 2021, 173: 105867. DOI: 10.1016/j.phrs.2021.105867.
    [21]
    LOUIS K, FADAKAR P, MACEDO C, et al. Concomitant loss of regulatory T and B cells is a distinguishing immune feature of antibody-mediated rejection in kidney transplantation[J]. Kidney Int, 2022, DOI: 10.1016/j.kint.2021.12.027[Epub ahead of print].
    [22]
    SIREN EMJ, LUO HD, TAM F, et al. Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers[J]. Nat Biomed Eng, 2021, 5(10): 1202-1216. DOI: 10.1038/s41551-021-00777-y.
    [23]
    WANG ZG, XU HE, CHENG FM, et al. Donor BMSC-derived small extracellular vesicles relieve acute rejection post-renal allograft through transmitting Loc108349490 to dendritic cells[J]. Aging Cell, 2021, 20(10): e13461. DOI: 10.1111/acel.13461.
    [24]
    CHENG H, XU B, ZHANG L, et al. Bortezomib alleviates antibody-mediated rejection in kidney transplantation by facilitating Atg5 expression[J]. J Cell Mol Med, 2021, 25(23): 10939-10949. DOI: 10.1111/jcmm.16998.
    [25]
    YANG Z, HAN F, LIAO T, et al. Artemisinin attenuates transplant rejection by inhibiting multiple lymphocytes and prolongs cardiac allograft survival[J]. Front Immunol, 2021, 12: 634368. DOI: 10.3389/fimmu.2021.634368.
    [26]
    YANG Y, NANKIVELL BJ, HUA W, et al. Renal tubular cell binding of β-catenin to TCF1 versus FoxO1 is associated with chronic interstitial fibrosis in transplanted kidneys[J]. Am J Transplant, 2021, 21(2): 727-739. DOI: 10.1111/ajt.16287.
    [27]
    YI Z, SALEM F, MENON MC, et al. Deep learning identified pathological abnormalities predictive of graft loss in kidney transplant biopsies[J]. Kidney Int, 2022, 101(2): 288-298. DOI: 10.1016/j.kint.2021.09.028.
    [28]
    GUI Z, SUO C, WANG Z, et al. Impaired ATG16L-dependent autophagy promotes renal interstitial fibrosis in chronic renal graft dysfunction through inducing EndMT by NF-κB signal pathway[J]. Front Immunol, 2021, 12: 650424. DOI: 10.3389/fimmu.2021.650424.
    [29]
    SUO C, GUI Z, WANG Z, et al. Bortezomib limits renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/P70S6K/Smurf2 pathway via IκBα protein stabilization[J]. Clin Sci (Lond), 2021, 135(1): 53-69. DOI: 10.1042/CS20201038.
    [30]
    LI Y, AN H, SHEN C, et al. Deep phenotyping of T cell populations under long-term treatment of tacrolimus and rapamycin in patients receiving renal transplantations by mass cytometry[J]. Clin Transl Med, 2021, 11(11): e629. DOI: 10.1002/ctm2.629.
    [31]
    LIU Y, LIU X, ZHOU S, et al. Single-cell profiling of kidney transplant recipients with immunosuppressive treatment reveals the dynamic immune characteristics[J]. Front Immunol, 2021, 12: 639942. DOI: 10.3389/fimmu.2021.639942.
    [32]
    ZHUANG Q, LI H, PENG B, et al. Single-cell transcriptomic analysis of peripheral blood reveals a novel B-cell subset in renal allograft recipients with accommodation[J]. Front Pharmacol, 2021, 12: 706580. DOI: 10.3389/fphar.2021.706580.
    [33]
    KITCHING AR, HICKEY MJ. Immune cell behaviour and dynamics in the kidney - insights from in vivo imaging[J]. Nat Rev Nephrol, 2022, 18(1): 22-37. DOI: 10.1038/s41581-021-00481-9.
    [34]
    NGUYEN VD, VAN NGUYEN H, SEO JW, et al. Prediction of acute rejection in kidney transplanted patients based on the point-of-care isothermal molecular diagnostics platform[J]. Biosens Bioelectron, 2022, 199: 113877. DOI: 10.1016/j.bios.2021.113877.
    [35]
    HAN F, SUN Q, HUANG Z, et al. Donor plasma mitochondrial DNA is associated with antibody-mediated rejection in renal allograft recipients[J]. Aging (Albany NY), 2021, 13(6): 8440-8453. DOI: 10.18632/aging.202654.
    [36]
    YE Y, HAN F, MA M, et al. Plasma macrophage migration inhibitory factor predicts graft function following kidney transplantation: a prospective cohort study[J]. Front Med (Lausanne), 2021, 8: 708316. DOI: 10.3389/fmed.2021.708316.
    [37]
    SENEV A, VAN LOON E, LERUT E, et al. Risk factors, histopathological features, and graft outcome of transplant glomerulopathy in the absence of donor-specific HLA antibodies[J]. Kidney Int, 2021, 100(2): 401-414. DOI: 10.1016/j.kint.2021.01.029.
    [38]
    WEI Y, CHEN X, ZHANG H, et al. Efficacy and safety of bone marrow-derived mesenchymal stem cells for chronic antibody-mediated rejection after kidney transplantation- a single-arm, two-dosing-regimen, phase Ⅰ/Ⅱ study[J]. Front Immunol, 2021, 12: 662441. DOI: 10.3389/fimmu.2021.662441.
    [39]
    ORANDI BJ, LONZE BE, JACKSON A, et al. Splenic irradiation for the treatment of severe antibody-mediated rejection[J]. Am J Transplant, 2016, 16(10): 3041-3045. DOI: 10.1111/ajt.13882.
    [40]
    ZHU L, GUO Z, SA R, et al. Case report: splenic irradiation for the treatment of chronic active antibody-mediated rejection in kidney allograft recipients with de novo donor-specific antibodies[J]. Front Immunol, 2021, 12: 661614. DOI: 10.3389/fimmu.2021.661614.
    [41]
    SHE S, WU X, ZHENG D, et al. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target[J]. J Hepatol, 2020, 72(3): 506-518. DOI: 10.1016/j.jhep.2019.09.033.
    [42]
    ZHAN P, LI H, HAN M, et al. PSMP is discriminative for chronic active antibody-mediated rejection and associate with intimal arteritis in kidney transplantation[J]. Front Immunol, 2021, 12: 661911. DOI: 10.3389/fimmu.2021.661911.
    [43]
    LUO Y, LUO F, ZHANG K, et al. Elevated circulating IL-10 producing breg, but not regulatory B cell levels, restrain antibody-mediated rejection after kidney transplantation[J]. Front Immunol, 2021, 11: 627496. DOI: 10.3389/fimmu.2020.627496.
    [44]
    WANG XD, LIU JP, SONG TR, et al. Kidney transplantation from hepatitis B surface antigen (HBsAg)-positive living donors to HBsAg-negative recipients: clinical outcomes at a high-volume center in China[J]. Clin Infect Dis, 2021, 72(6): 1016-1023. DOI: 10.1093/cid/ciaa178.
    [45]
    YU Y, WEI C, LYU J, et al. Donor-derived human parvovirus B19 infection in kidney transplantation[J]. Front Cell Infect Microbiol, 2021, 11: 753970. DOI: 10.3389/fcimb.2021.753970.
    [46]
    TANG JL, ABBASI K. What can the world learn from China's response to COVID-19?[J]. BMJ, 2021, 375: n2806. DOI: 10.1136/bmj.n2806.
    [47]
    CHEN JJ, KUO G, LEE TH, et al. Incidence of mortality, acute kidney injury and graft loss in adult kidney transplant recipients with coronavirus disease 2019: systematic review and Meta-analysis[J]. J Clin Med, 2021, 10(21): 5162. DOI: 10.3390/jcm10215162.
    [48]
    AO G, WANG Y, QI X, et al. The association between severe or death COVID-19 and solid organ transplantation: a systematic review and Meta-analysis[J]. Transplant Rev (Orlando), 2021, 35(3): 100628. DOI: 10.1016/j.trre.2021.100628.
    [49]
    CHEN T, LI X, LI Q, et al. COVID-19 vaccination hesitancy and associated factors among solid organ transplant recipients in China[J]. Hum Vaccin Immunother, 2021, 17(12): 4999-5006. DOI: 10.1080/21645515.2021.1984133.
    [50]
    SWAI J, GUI M, LONG M, et al. Humoral and cellular immune response to severe acute respiratory syndrome coronavirus-2 vaccination in haemodialysis and kidney transplant patients[J]. Nephrology (Carlton), 2022, 27(1): 7-24. DOI: 10.1111/nep.13974.
    [51]
    CAI Z, CAI X, SONG Y, et al. Psychological distress and its association with quality of life in organ transplant recipients during COVID-19 pandemic[J]. Front Psychiatry, 2021, 12: 690295. DOI: 10.3389/fpsyt.2021.690295.
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