Citation: | Zhou Aiwei, Liu Yuan, Xue Feng, et al. Research progress on immune tolerance after pediatric liver transplantation[J]. ORGAN TRANSPLANTATION, 2022, 13(3): 288-295. doi: 10.3969/j.issn.1674-7445.2022.03.002 |
[1] |
中华医学会器官移植学分会. 中国儿童肝移植操作规范(2019版)[J/CD]. 中华移植杂志(电子版), 2019, 13(3): 181-186. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.005.
Branch of Organ Transplantation of Chinese Medical Association. Technical operation specification for pediatric liver transplantation in China (2019 edition)[J/CD]. Chin J Transplant (Electr Edit), 2019, 13(3): 181-186. DOI: 10.3877/cma.j.issn.1674-3903.2019.03.005.
|
[2] |
SPINNER JA, DENFIELD SW. Immunosuppressant drugs and their effects on children undergoing solid organ transplant[J]. Pediatr Rev, 2022, 43(2): 71-86. DOI: 10.1542/pir.2020-000620.
|
[3] |
杨扬, 邓宜南. 肝细胞癌肝移植术后免疫抑制剂的应用[J]. 临床肝胆病杂志, 2021, 37(2): 263-266. DOI: 10.3969/j.issn.1001-5256.2021.02.005.
YANG Y, DENG YN. Application of immunosuppressants after liver transplantation for hepatocellular carcinoma[J]. J Clin Hepatol, 2021, 37(2): 263-266. DOI: 10.3969/j.issn.1001-5256.2021.02.005.
|
[4] |
中华医学会器官移植学分会. 器官移植免疫抑制剂临床应用技术规范(2019版)[J]. 器官移植, 2019, 10(3): 213-226. DOI: 10.3969/j.issn.1674-7445.2019.03.001.
Branch of Organ Transplantation of Chinese Medical Association. Technical specifcation for clinical application of immunosuppressive agents in organ transplantation (2019 edition)[J]. Organ Transplant, 2019, 10(3): 213-226. DOI: 10.3969/j.issn.1674-7445.2019.03.001.
|
[5] |
KOVAC D, CHOE J, LIU E, et al. Immunosuppression considerations in simultaneous organ transplant[J]. Pharmacotherapy, 2021, 41(1): 59-76. DOI: 10.1002/phar.2495.
|
[6] |
ÅBERG F, ISONIEMI H, PUKKALA E, et al. Cancer after liver transplantation in children and young adults: a population-based study from 4 Nordic countries[J]. Liver Transpl, 2018, 24(9): 1252-1259. DOI: 10.1002/lt.25305.
|
[7] |
PARMAR A, VANDRIEL SM, NG VL. Health-related quality of life after pediatric liver transplantation: a systematic review[J]. Liver Transpl, 2017, 23(3): 361-374. DOI: 10.1002/lt.24696.
|
[8] |
PHAM YH, MILOH T. Liver transplantation in children[J]. Clin Liver Dis, 2018, 22(4): 807-821. DOI: 10.1016/j.cld.2018.06.004.
|
[9] |
HOEGY D, BLEYZAC N, ROBINSON P, et al. Medication adherence in pediatric transplantation and assessment methods: a systematic review[J]. Patient Prefer Adherence, 2019, 13: 705-719. DOI: 10.2147/PPA.S200209.
|
[10] |
KELLY D, WRAY J. Non-adherence and transition clinics[J]. Best Pract Res Clin Gastroenterol, 2020, 46/47: 101687. DOI: 10.1016/j.bpg.2020.101687.
|
[11] |
王凯, 高伟. 儿童肝移植免疫耐受相关进展[J]. 临床肝胆病杂志, 2019, 35(11): 2402-2407. DOI: 10.3969/j.issn.1001-5256.2019.11.005.
WANG K, GAO W. Research advances in immune tolerance in children receiving liver transplantation[J]. J Clin Hepatol, 2019, 35(11): 2402-2407. DOI: 10.3969/j.issn.1001-5256.2019.11.005.
|
[12] |
CVETKOVSKI F, HEXHAM JM, BERGLUND E. Strategies for liver transplantation tolerance[J]. Int J Mol Sci, 2021, 22(5): 2253. DOI: 10.3390/ijms22052253.
|
[13] |
MCCAUGHAN GW, BOWEN DG, BERTOLINO PJ. Induction phase of spontaneous liver transplant tolerance[J]. Front Immunol, 2020, 11: 1908. DOI: 10.3389/fimmu.2020.01908.
|
[14] |
REYES J, ZEEVI A, RAMOS H, et al. Frequent achievement of a drug-free state after orthotopic liver transplantation[J]. Transplant Proc, 1993, 25(6): 3315-3319.
|
[15] |
NI X, WANG Q, GU J, et al. Clinical and basic research progress on treg-induced immune tolerance in liver transplantation[J]. Front Immunol, 2021, 12: 535012. DOI: 10.3389/fimmu.2021.535012.
|
[16] |
APPENZELLER-HERZOG C, HARTLEIF S, VIONNET J. Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: a scoping review[J]. Am J Transplant, 2021, 21(10): 3312-3323. DOI: 10.1111/ajt.16585.
|
[17] |
STOLP J, ZAITSU M, WOOD KJ. Immune tolerance and rejection in organ transplantation[J]. Methods Mol Biol, 2019, 1899: 159-180. DOI: 10.1007/978-1-4939-8938-6_12.
|
[18] |
VIONNET J, SÁNCHEZ-FUEYO A. Biomarkers of immune tolerance in liver transplantation[J]. Hum Immunol, 2018, 79(5): 388-394. DOI: 10.1016/j.humimm.2018.02.010.
|
[19] |
WAN P, XU D, ZHANG J, et al. Liver transplantation for biliary atresia: a nationwide investigation from 1996 to 2013 in mainland China[J]. Pediatr Transplant, 2016, 20(8): 1051-1059. DOI: 10.1111/petr.12750.
|
[20] |
SCHREIBER RA, HARPAVAT S, HULSCHER JBF, et al. Biliary atresia in 2021: epidemiology, screening and public policy[J]. J Clin Med, 2022, 11(4): 999. DOI: 10.3390/jcm11040999.
|
[21] |
VIJ M, RELA M. Biliary atresia: pathology, etiology and pathogenesis[j]. Future Sci OA, 2020, 6(5): FSO466. DOI: 10.2144/fsoa-2019-0153.
|
[22] |
常青锋, 王静, 宋翠萍. 活体肝移植治疗胆道闭锁儿童临床疗效研究[J]. 实用肝脏病杂志, 2021, 24(3): 431-434. DOI: 10.3969/j.issn.1672-5069.2021.03.032.
CHANG QF, WANG J, SONG CP. Clinical efficacy of living donor liver transplantation for treatment of children with biliary atresia[J]. J Pract Hepatol, 2021, 24(3): 431-434. DOI: 10.3969/j.issn.1672-5069.2021.03.032.
|
[23] |
高伟, 王凯, 马楠, 等. 亲属活体肝移植治疗儿童胆道闭锁306例临床分析[J]. 中华器官移植杂志, 2019, 40(1): 13-17. DOI: 10.3760/cma.j.issn.0254-1785.2019.01.004.
GAO W, WANG K, MA N, et al. Living donor liver transplantations for pediatric patients with biliary atresia in a single center: 306[J]. Chin J Organ Transplant, 2019, 40(1): 13-17. DOI: 10.3760/cma.j.issn.0254-1785.2019.01.004.
|
[24] |
FENG S, DEMETRIS AJ, SPAIN KM, et al. Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R[J]. Hepatology, 2017, 65(2): 647-660. DOI: 10.1002/hep.28681.
|
[25] |
FENG S, EKONG UD, LOBRITTO SJ, et al. Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants[J]. JAMA, 2012, 307(3): 283-293. DOI: 10.1001/jama.2011.2014.
|
[26] |
FENG S, BUCUVALAS JC, MAZARIEGOS GV, et al. Efficacy and safety of immunosuppression withdrawal in pediatric liver transplant recipients: moving toward personalized management[J]. Hepatology, 2021, 73(5): 1985-2004. DOI: 10.1002/hep.31520.
|
[27] |
YOSHITOMI M, KOSHIBA T, HAGA H, et al. Requirement of protocol biopsy before and after complete cessation of immunosuppression after liver transplantation[J]. Transplantation, 2009, 87(4): 606-614. DOI: 10.1097/TP.0b013e318195a7cb.
|
[28] |
CASIRAGHI F, PERICO N, REMUZZI G. Mesenchymal stromal cells for tolerance induction in organ transplantation[J]. Hum Immunol, 2018, 79(5): 304-313. DOI: 10.1016/j.humimm.2017.12.008.
|
[29] |
LU J, LI P, DU X, et al. Regulatory T cells induce transplant immune tolerance[J]. Transpl Immunol, 2021, 67: 101411. DOI: 10.1016/j.trim.2021.101411.
|
[30] |
TRAN L, HUMAR A. Tolerance studies in liver transplantation: are we fooling ourselves?[J]. Curr Opin Organ Transplant, 2020, 25(2): 151-157. DOI: 10.1097/MOT.0000000000000738.
|
[31] |
TODO S, YAMASHITA K, GOTO R, et al. A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation[J]. Hepatology, 2016, 64(2): 632-643. DOI: 10.1002/hep.28459.
|
[32] |
LI J, THOMSON AW, ROGERS NM. Myeloid and mesenchymal stem cell therapies for solid organ transplant tolerance[J]. Transplantation, 2021, 105(12): e303-e321. DOI: 10.1097/TP.0000000000003765.
|
[33] |
DAI H, ZHENG Y, THOMSON AW, et al. Transplant tolerance induction: insights from the liver[J]. Front Immunol, 2020, 11: 1044. DOI: 10.3389/fimmu.2020.01044.
|
[34] |
YOU Y, WEN DG, GONG JP, et al. Research status of mesenchymal stem cells in liver transplantation[J]. Cell Transplant, 2019, 28(12): 1490-1506. DOI: 10.1177/0963689719874786.
|
[35] |
THOMSON AW, HUMAR A, LAKKIS FG, et al. Regulatory dendritic cells for promotion of liver transplant operational tolerance: rationale for a clinical trial and accompanying mechanistic studies[J]. Hum Immunol, 2018, 79(5): 314-321. DOI: 10.1016/j.humimm.2017.10.017.
|
[36] |
DU X, CHANG S, GUO W, et al. Progress in liver transplant tolerance and tolerance-inducing cellular therapies[J]. Front Immunol, 2020, 11: 1326. DOI: 10.3389/fimmu.2020.01326.
|
[37] |
WANG P, JIANG Z, WANG C, et al. Immune tolerance induction using cell-based strategies in liver transplantation: clinical perspectives[J]. Front Immunol, 2020, 11: 1723. DOI: 10.3389/fimmu.2020.01723.
|
[38] |
JIANG Y, QUE W, ZHU P, et al. The role of diverse liver cells in liver transplantation tolerance[J]. Front Immunol, 2020, 11: 1203. DOI: 10.3389/fimmu.2020.01203.
|
[39] |
OWEN A, NEWSOME PN. Mesenchymal stromal cells, a new player in reducing complications from liver transplantation?[J]. Front Immunol, 2020, 11: 1306. DOI: 10.3389/fimmu.2020.01306.
|
[40] |
JOHNSTONE BH, MESSNER F, BRANDACHER G, et al. A large-scale bank of organ donor bone marrow and matched mesenchymal stem cells for promoting immunomodulation and transplant tolerance[J]. Front Immunol, 2021, 12: 622604. DOI: 10.3389/fimmu.2021.622604.
|
[41] |
MAZARIEGOS GV, REYES J, MARINO I, et al. Risks and benefits of weaning immunosuppression in liver transplant recipients: long-term follow-up[J]. Transplant Proc, 1997, 29(1/2): 1174-1177. DOI: 10.1016/s0041-1345(96)00535-0.
|
[42] |
DEVLIN J, DOHERTY D, THOMSON L, et al. Defining the outcome of immunosuppression withdrawal after liver transplantation[J]. Hepatology, 1998, 27(4): 926-933. DOI: 10.1002/hep.510270406.
|
[43] |
TAKATSUKI M, UEMOTO S, INOMATA Y, et al. Weaning of immunosuppression in living donor liver transplant recipients[J]. Transplantation, 2001, 72(3): 449-454. DOI: 10.1097/00007890-200108150-00016.
|
[44] |
OIKE F, YOKOI A, NISHIMURA E, et al. Complete withdrawal of immunosuppression in living donor liver transplantation[J]. Transplant Proc, 2002, 34(5): 1521. DOI: 10.1016/s0041-1345(02)02980-9.
|
[45] |
EASON JD, COHEN AJ, NAIR S, et al. Tolerance: is it worth the risk?[J]. Transplantation, 2005, 79(9): 1157-1159. DOI: 10.1097/01.tp.0000162084.46555.10.
|
[46] |
TRYPHONOPOULOS P, TZAKIS AG, WEPPLER D, et al. The role of donor bone marrow infusions in withdrawal of immunosuppression in adult liver allotransplantation[J]. Am J Transplant, 2005, 5(3): 608-613. DOI: 10.1111/j.1600-6143.2004.00743.x.
|
[47] |
TRYPHONOPOULOS P, RUIZ P, WEPPLER D, et al. Long-term follow-up of 23 operational tolerant liver transplant recipients[J]. Transplantation, 2010, 90(12): 1556-1561. DOI: 10.1097/TP.0b013e3182003db7.
|
[48] |
TISONE G, ORLANDO G, CARDILLO A, et al. Complete weaning off immunosuppression in HCV liver transplant recipients is feasible and favourably impacts on the progression of disease recurrence[J]. J Hepatol, 2006, 44(4): 702-709. DOI: 10.1016/j.jhep.2005.11.047.
|
[49] |
ORLANDO G, MANZIA T, BAIOCCHI L, et al. The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: the updated follow up at 78 months[J]. Transpl Immunol, 2008, 20(1/2): 43-47. DOI: 10.1016/j.trim.2008.08.007.
|
[50] |
ASSY N, ADAMS PC, MYERS P, et al. Randomized controlled trial of total immunosuppression withdrawal in liver transplant recipients: role of ursodeoxycholic acid[J]. Transplantation, 2007, 83(12): 1571-1576. DOI: 10.1097/01.tp.0000266678.32250.76.
|
[51] |
PONS JA, RAMÍREZ P, REVILLA-NUIN B, et al. Immunosuppression withdrawal improves long-term metabolic parameters, cardiovascular risk factors and renal function in liver transplant patients[J]. Clin Transplant, 2009, 23(3): 329-336. DOI: 10.1111/j.1399-0012.2008.00944.x.
|
[52] |
DE LA GARZA RG, SAROBE P, MERINO J, et al. Trial of complete weaning from immunosuppression for liver transplant recipients: factors predictive of tolerance[J]. Liver Transpl, 2013, 19(9): 937-944. DOI: 10.1002/lt.23686.
|
[53] |
LIN NC, WANG HK, YEH YC, et al. Minimization or withdrawal of immunosuppressants in pediatric liver transplant recipients[J]. J Pediatr Surg, 2015, 50(12): 2128-2133. DOI: 10.1016/j.jpedsurg.2015.08.043.
|
[54] |
LEVITSKY J, BURRELL BE, KANAPARTHI S, et al. Immunosuppression withdrawal in liver transplant recipients on sirolimus[J]. Hepatology, 2020, 72(2): 569-583. DOI: 10.1002/hep.31036.
|
[55] |
BENÍTEZ C, LONDOÑO MC, MIQUEL R, et al. Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients[J]. Hepatology, 2013, 58(5): 1824-1835. DOI: 10.1002/hep.26426.
|
[56] |
JUCAUD V, SHAKED A, DESMARAIS M, et al. Prevalence and impact of de novo donor-specific antibodies during a multicenter immunosuppression withdrawal trial in adult liver transplant recipients[J]. Hepatology, 2019, 69(3): 1273-1286. DOI: 10.1002/hep.30281.
|
[57] |
SHAKED A, DESMARAIS MR, KOPETSKIE H, et al. Outcomes of immunosuppression minimization and withdrawal early after liver transplantation[J]. Am J Transplant, 2019, 19(5): 1397-1409. DOI: 10.1111/ajt.15205.
|
[58] |
POPP FC, FILLENBERG B, EGGENHOFER E, et al. Safety and feasibility of third-party multipotent adult progenitor cells for immunomodulation therapy after liver transplantation--a phase I study (MISOT-I)[J]. J Transl Med, 2011, 9: 124. DOI: 10.1186/1479-5876-9-124.
|
[59] |
DETRY O, VANDERMEULEN M, DELBOUILLE MH, et al. Infusion of mesenchymal stromal cells after deceased liver transplantation: a phase Ⅰ-Ⅱ, open-label, clinical study[J]. J Hepatol, 2017, 67(1): 47-55. DOI: 10.1016/j.jhep.2017.03.001.
|
[60] |
ZHANG YC, LIU W, FU BS, et al. Therapeutic potentials of umbilical cord-derived mesenchymal stromal cells for ischemic-type biliary lesions following liver transplantation[J]. Cytotherapy, 2017, 19(2): 194-199. DOI: 10.1016/j.jcyt.2016.11.005.
|
[61] |
SOEDER Y, LOSS M, JOHNSON CL, et al. First-in-human case study: multipotent adult progenitor cells for immunomodulation after liver transplantation[J]. Stem Cells Transl Med, 2015, 4(8): 899-904. DOI: 10.5966/sctm.2015-0002.
|
[62] |
SHI M, LIU Z, WANG Y, et al. A pilot study of mesenchymal stem cell therapy for acute liver allograft rejection[J]. Stem Cells Transl Med, 2017, 6(12): 2053-2061. DOI: 10.1002/sctm.17-0134.
|
[63] |
ClinicalTrials. gov[EB/OL]. [2022-01-15]. https://clinicaltrials.gov/.
|
[64] |
LI M, ZHAO W, WANG Y, et al. A wave of Foxp3+ regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance[J]. Cell Mol Immunol, 2020, 17(5): 507-518. DOI: 10.1038/s41423-019-0246-9.
|
[65] |
HALMA J, PIERCE S, MCLENNAN R, et al. Natural killer cells in liver transplantation: can we harness the power of the immune checkpoint to promote tolerance?[J]. Clin Transl Sci, 2021, DOI: 10.1111/cts.13208[Epub ahead of print].
|
[66] |
WANG K, SONG ZL, WU B, et al. Different phenotypes of CD4+CD25+Foxp3+ regulatory T cells in recipients post liver transplantation[J]. Int Immunopharmacol, 2019, 69: 194-201. DOI: 10.1016/j.intimp.2019.01.048.
|
[67] |
MARTÍNEZ-LLORDELLA M, LOZANO JJ, PUIG-PEY I, et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients[J]. J Clin Invest, 2008, 118(8): 2845-2857. DOI: 10.1172/JCI35342.
|
[68] |
LAU AH, VITALONE MJ, HAAS K, et al. Mass cytometry reveals a distinct immunoprofile of operational tolerance in pediatric liver transplantation[J]. Pediatr Transplant, 2016, 20(8): 1072-1080. DOI: 10.1111/petr.12795.
|
[69] |
LI Y, KOSHIBA T, YOSHIZAWA A, et al. Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation[J]. Am J Transplant, 2004, 4(12): 2118-2125. DOI: 10.1111/j.1600-6143.2004.00611.x.
|
[70] |
BOHNE F, MARTÍNEZ-LLORDELLA M, LOZANO JJ, et al. Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation[J]. J Clin Invest, 2012, 122(1): 368-382. DOI: 10.1172/JCI59411.
|